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The role of methionine on metabolism, oxidative stress, and diseases

Abstract

Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.

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Acknowledgements

This research was supported by National Natural Science Foundation of China (No. 31772642), International Partnership Program of Chinese Academy of Sciences (161343KYSB20160008), National Key Research and Development Program of China (2016YFD0500504), and Chinese Academy of Sciences visiting professorship for senior international scientists Grant no. 2016VBB007.

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Correspondence to Gang Liu.

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Handling Editors: C.-A.A. Hu, Y. Yin, Y. Hou, G. Wu, Y. Teng.

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Martínez, Y., Li, X., Liu, G. et al. The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids 49, 2091–2098 (2017). https://doi.org/10.1007/s00726-017-2494-2

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Keywords

  • Methionine
  • Mammalian
  • Endogenous antioxidant enzyme
  • ROS
  • Cancer
  • Disease