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N w-hydroxy-l-arginine as a novel ethnic specific indicator of estrogen-negative breast cancer

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Abstract

As a heterogeneous disease, breast cancer can be divided into distinct subtypes. Among the two major subsets of estrogen receptor-negative (ER−) and ER-positive (ER+) tumors, the ER− is a more aggressive subtype, more difficult to treat, has greater ethnic disparity concerns, worse prognosis, and almost twice the risk of mortality. We provide here a fundamental delineation of N w-hydroxy-l-arginine as a sensitive and reliable ethnic specific indicator for ER− breast cancer early-prognosis (United States provisional patent application number 62232816).

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Acknowledgments

The University of New England Office of Research and Scholarship, and the College of Pharmacy provided funding support to this study.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of New England, Portland, ME, 04103, USA

    Srinidi Mohan, Nancy Moua & Lisa Harding

Authors
  1. Srinidi Mohan
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  2. Nancy Moua
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  3. Lisa Harding
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Corresponding author

Correspondence to Srinidi Mohan.

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Conflict of interest

As authors of this manuscript, we declare no conflict of interest; either financial or otherwise.

Research involving human participants and/or animals

No human participants were directly involved with this project. All blood samples used in this study came from bio-banks.

Informed consent

Only de-identified patient samples from bio-banks were used for this study, thus exempting informed consent requirement.

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Handling Editor: G. J. Peters.

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Mohan, S., Moua, N. & Harding, L. N w-hydroxy-l-arginine as a novel ethnic specific indicator of estrogen-negative breast cancer. Amino Acids 48, 2693–2698 (2016). https://doi.org/10.1007/s00726-016-2301-5

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  • DOI: https://doi.org/10.1007/s00726-016-2301-5

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