Amino Acids

, Volume 47, Issue 2, pp 271–279

Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update

Part I: preparations of ethynylglycine synthon
  • Zohra Benfodda
  • David Bénimélis
  • Gianna Reginato
  • Patrick Meffre
Minireview Article

Abstract

The ethynylglycine synthon {(R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine} is a chiral compound with valuable synthetic interest. An update on the different routes for its synthesis is reviewed and discussed.

Keywords

Synthesis Ethynylglycine synthon Bestmann-Ohira Corey-Fuchs 

Abbreviations

Boc

Tert-butoxycarbonyl

Cbz

Benzyloxycarbonyl

DIBAL-H

Diisobutylaluminum hydride

TEMPO

2,2,6,6-Tetramethylpiperidine 1-oxyl

Ts

4-toluenesulfonyl

ent-x

Enantiomer of compound x

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Zohra Benfodda
    • 1
    • 2
  • David Bénimélis
    • 1
    • 2
  • Gianna Reginato
    • 3
  • Patrick Meffre
    • 1
    • 2
  1. 1.IBMM-UMR 5247-CNRS-Universités Montpellier 1 et 2Montpellier Cedex 5France
  2. 2.UNIV. NIMES, EA7352 CHROMENîmes Cedex 1France
  3. 3.ICCOM–CNRSesto FiorentinoItaly

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