Contributions of aminoacyl-tRNA synthetase-interacting multifunctional protein-3 to mammalian translation initiation
Aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) stabilizes and protects mammalian methionyl-tRNA synthetase (MRS) and eukaryotic initiation factor 2 subunit gamma (eIF2γ), factors involved in the formation and the delivery of Met-tRNA i Met respectively, through the binding interactions. Due to the protections that MRS and eIF2γ are provided from the interactions with AIMP3, cellular levels of MRS and eIF2γ may be able to be maintained high enough for their canonical and/or non-canonical functions.
KeywordsAminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) Methionyl-tRNA synthetase (MRS) Eukaryotic initiation factor 2 subunit gamma (eIF2γ) Protein–protein interaction Translation initiation
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology of Korea (2010-0023292).
- Kwon NH, Kang T, Lee JY, Kim HH, Kim HR, Hong J, Oh YS, Han JM, Ku MJ, Lee SY, Kim S (2011) Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3. Proc Natl Acad Sci USA 108(49):19635–19640PubMedCrossRefGoogle Scholar