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Amino Acids

, Volume 46, Issue 1, pp 73–80 | Cite as

Taurine and atherosclerosis

  • Shigeru MurakamiEmail author
Review Article

Abstract

Taurine is abundantly present in most mammalian tissues and plays a role in many important physiological functions. Atherosclerosis is the underlying mechanism of cardiovascular disease including myocardial infarctions, strokes and peripheral artery disease and remains a major cause of morbidity and mortality worldwide. Studies conducted in laboratory animal models using both genetic and dietary models of hyperlipidemia have demonstrated that taurine supplementation retards the initiation and progression of atherosclerosis. Epidemiological studies have also suggested that taurine exerts preventive effects on cardiovascular diseases. The present review focuses on the effects of taurine on the pathogenesis of atherosclerosis. In addition, the potential mechanisms by which taurine suppress the development of atherosclerosis will be discussed.

Keywords

Taurine Atherosclerosis Cardiovascular disease Artery 

Abbreviations

CYP

Cytochrome P450

HDL

High density lipoprotein

HepG2

Human hepatocellular liver carcinoma cell line

HMG-CoA

3-Hydroxy-3-methylglutaryl coenzyme A

HUVEC

Human umbilical vein endothelial cells

ICAM-1

Intercellular adhesion molecule-1

I-kB

Inhibitor of nuclear factorκ-B

LDL

Low density lipoprotein

LOX-1

Lectin-like oxidized low density lipoprotein receptor-1

NF-κB

Nuclear factor-κB

NO

Nitric oxide

PDGF

Platelet-derived growth factor

ROS

Reactive oxygen species

SMC

Smooth muscle cell

Tau-Cl

Taurine chloramine

TNF-α

Tumor necrosis factor-α

VLDL

Very low density lipoprotein

Notes

Conflict of interest

The authors declare that there are no conflicts of interest associated with this study.

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  1. 1.R&D Headquarters, Self Medication BusinessTaisho Pharmaceutical Co LtdTokyoJapan

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