Taurine and central nervous system disorders

Abstract

In the present era, investigators seek to find therapeutic interventions that are multifaceted in their mode of action. Such targets provide the most advantageous routes for addressing the multiplicity of pathophysiological avenues that lead to neuronal dysfunction and death observed in neurological disorders and neurodegenerative diseases. Taurine, an endogenous amino acid, exhibits a plethora of physiological functions in the central nervous system. In this review, we describe the mode of action of taurine and its clinical application in the neurological diseases: Alzheimer’s disease, Parkinson’s disease and Huntington’s disease.

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Acknowledgments

This work was supported, in part, by the James and Esther King Biomedical Research Program, Florida Department of Health (grant #: 09KW-11), and the Schmidt Foundation, Charles E. Schmidt College of Medicine, Florida Atlantic University.

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Correspondence to Howard Prentice or Jang-Yen Wu.

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Menzie, J., Pan, C., Prentice, H. et al. Taurine and central nervous system disorders. Amino Acids 46, 31–46 (2014). https://doi.org/10.1007/s00726-012-1382-z

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Keywords

  • Taurine
  • Neuroprotective mechanisms
  • Alzheimer’s disease
  • Parkinson’s disease
  • Huntington’s disease