Abstract
Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined by Marfey’s method. NW-G10 (1) and NW-G11 (2) exhibited significant activity against Gram-positive bacteria, such as Bacillus cereus, Bacillus subtilis and Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), but they are not active against gram negatives.
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Acknowledgments
This study was supported part by the grant of The National Key Basic Research Program (973 Program, 2010CB126100) from Science and Technology Ministry of China, the National Natural Science Foundation of China (No. 30971935), Postdoctoral Science Foundation of China (20100471644 and 201104683), and Program for New Century Excellent Talents in University from Education Ministry of China.
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Wei, S., Fan, L., Wu, W. et al. Two piperazic acid-containing cyclic hexapeptides from Streptomyces alboflavus 313. Amino Acids 43, 2191–2198 (2012). https://doi.org/10.1007/s00726-012-1303-1
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DOI: https://doi.org/10.1007/s00726-012-1303-1