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Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress

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Abstract

The novel synthetic derivative of carnosine, (S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carbonyl-β-alanyl-l-histidine (S-Trolox™-Carnosine, STC) increases the resistance of rats to experimental acute hypobaric hypoxia (AHH) thus protecting brain from the oxidative damage. This effect is accompanied by better preservation of the acquired skills in Morris water maze possibly by increasing efficiency of the brain antioxidant system. In addition, STC caused an increase in life span of both male and female fruit fly Drosophila melanogaster whereas carnosine increased life span only in male fruit flies. The results indicate that development of the drug based on STC could be beneficial in neurology and gerontology.

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Acknowledgments

Supported by RFBR Grants ## 09-04-00505, 10-04-01461, and 11-04-00906.

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Authors and Affiliations

  1. Research Center of Neurology, Volokolamskoe shosse 80, 123367, Moscow, Russia

    S. Stvolinsky & A. Boldyrev

  2. Moscow State University, Lenin’s Hills, 119992, Moscow, Russia

    K. Toropova, M. Gordeeva & A. Boldyrev

  3. Chemical Diversity Research Institute, 2a Rabochaya St, 141400, Khimki, Moscow Region, Russia

    V. Kazey

  4. Hamari Chemicals, Ltd, 1-4-29, Kunijima, Higashi-Yodogawa-ku, Osaka, 533-0024, Japan

    T. Sato & K. Meguro

Authors
  1. S. Stvolinsky
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  2. K. Toropova
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  3. M. Gordeeva
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  4. V. Kazey
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  5. T. Sato
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  6. K. Meguro
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  7. A. Boldyrev
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Corresponding author

Correspondence to A. Boldyrev.

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To the memory of Steven Gallant, enthusiast in carnosine biochemistry

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Stvolinsky, S., Toropova, K., Gordeeva, M. et al. Carnosine and its (S)-Trolox™ derivative protect animals against oxidative stress. Amino Acids 43, 165–170 (2012). https://doi.org/10.1007/s00726-012-1256-4

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  • DOI: https://doi.org/10.1007/s00726-012-1256-4

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