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Transglutaminases and receptor tyrosine kinases

Amino Acids volume 44, pages 19–24 (2013)Cite this article

Abstract

Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling. We cite literature that confirms and suggests the formation of integrin:RTK:transglutaminase complexes and explores the occurrence and functionality of these complexes in a large fraction of the RTK family.

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Acknowledgments

Queensland University of Technology has filed a patent related to Transglutaminases and insulin-like growth factors. An inventorship audit is underway and all the authors of this paper may be deemed inventors. Tissue Therapies Ltd, a company spun out of Queensland University of Technology, has a license to commercialize this intellectual property. Z.U holds shares in and is a consultant for Tissue Therapies Ltd.

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Affiliations

  1. Tissue Repair and Regeneration Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove Qld, 4059, Australia

    Manaswini Sivaramakrishnan, Gary K. Shooter, Zee Upton & Tristan I. Croll

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  1. Manaswini Sivaramakrishnan
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  2. Gary K. Shooter
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  3. Zee Upton
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  4. Tristan I. Croll
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Correspondence to Manaswini Sivaramakrishnan.

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Sivaramakrishnan, M., Shooter, G.K., Upton, Z. et al. Transglutaminases and receptor tyrosine kinases. Amino Acids 44, 19–24 (2013). https://doi.org/10.1007/s00726-011-1113-x

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  • DOI: https://doi.org/10.1007/s00726-011-1113-x

Keywords

  • Transglutaminases
  • Integrins
  • Extracellular matrix
  • Receptor tyrosine kinases
  • Tissue transglutaminase
  • Fibronectin