Abstract
Silaproline is an analogue of proline, which exhibits similar conformational properties. Moreover, the presence of dimethylsilyl group confers to silaproline a higher lipophilicity as well as an improved resistance to biodegradation. This report describes the comparison of two routes to obtain Fmoc-(l) Sip-OH on the gram scale using chiral HPLC resolution.
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Martin, C., Vanthuyne, N., Miramon, H. et al. Resolution of protected silaproline for a gram scale preparation. Amino Acids 43, 649–655 (2012). https://doi.org/10.1007/s00726-011-1112-y
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DOI: https://doi.org/10.1007/s00726-011-1112-y