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Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function

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Abstract

S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin. They are of major interest because of their putative functional roles in innate immunity, epidermal cell maturation, and epithelial tumorigenesis. Human S100A7 and S100A15 have lately evolved by gene duplications within the epidermal differentiation complex (chromosome 1q21) during primate evolution forming a novel S100 subfamily. Therefore, S100A7 and S100A15 are almost identical in sequence (>90%) and are difficult to discriminate. Despite their high homology, S100A7 and S100A15 are distinct in tissue distribution, regulation, and function, and thus, exemplary for the diversity within the S100 family. Their different properties are compelling reasons to discriminate S100A7 (psoriasin) and S100A15 (koebnerisin) in epithelial homeostasis, inflammation, and cancer.

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Abbreviations

UTR:

Untranslated region

EDC:

Epidermal differentiation complex

S100A15-L:

Long human S100A15 transcript

S100A15-S:

Short human S100A15 transcript

TLR:

Toll-like receptor

RAGE:

Receptor of advanced glycated end products

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Acknowledgments

This work was supported by grants from the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and the German Research Foundation (DFG).

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Authors and Affiliations

  1. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Ronald Wolf & Stuart H. Yuspa

  2. Department of Dermatology, Ludwig-Maximilian University Munich, Frauenlobstrasse 9-11, 80337, Munich, Germany

    Ronald Wolf & Thomas Ruzicka

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  1. Ronald Wolf
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  2. Thomas Ruzicka
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Correspondence to Ronald Wolf.

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Wolf, R., Ruzicka, T. & Yuspa, S.H. Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function. Amino Acids 41, 789–796 (2011). https://doi.org/10.1007/s00726-010-0666-4

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