Summary.
Three groups of chloroenyne-modified amino acids were synthesized. Chloroenyne moiety was attached at the N- or C-terminal amino acid (Tyr, Phe, Val, Gly, Lys) position carrying different protecting groups. Prepared derivatives will be used as building blocks in the synthesis of enediyne-peptide conjugates. Furthermore, reactivity of modified amino acids in the peptide bond formation reaction was tested.
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Authors’ address: Dr. Ivanka Jerić, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, POB 180, 10002 Zagreb, Croatia
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Gredičak, M., Kolonić, A. & Jerić, I. Novel chloroenyne-modified amino acid derivatives. Amino Acids 35, 185–194 (2008). https://doi.org/10.1007/s00726-007-0572-6
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DOI: https://doi.org/10.1007/s00726-007-0572-6