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The effect of glutamine supplementation and physical exercise on neutrophil function

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Summary.

Glutamine is the most abundant free amino acid in the body. Its primary source is skeletal muscle, from where it is released into the bloodstream and transported to a variety of tissues. Several studies have shown that glutamine is important for rat and human neutrophil function and that these cells utilize glutamine at high rates. Physical exercise has also been shown to induce considerable changes in neutrophil metabolism and function. As neutrophils represent 50–60% of the total circulating leukocyte pool and play a key role in inflammation, both physical exercise and glutamine might be expected to regulate the inflammatory process. In this review, the changes in neutrophil function induced by physical exercise and glutamine supplementation are compared.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil

    C. J. Lagranha, A. C. Levada-Pires, J. Procopio & R. Curi

  2. Department of Medicine, Uniformed Services, University of Health Sciences, Bethesda, MD, U.S.A.

    D. F. Sellitti

  3. Biological Sciences and Health Center, Cruzeiro do Sul University, SP, Brazil

    T. C. Pithon-Curi

Authors
  1. C. J. Lagranha
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  2. A. C. Levada-Pires
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  3. D. F. Sellitti
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  4. J. Procopio
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  5. R. Curi
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  6. T. C. Pithon-Curi
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Authors’ address: Claudia J. Lagranha, Ph.D., Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes 1524, 05508-900 Butantan, SP, Brazil

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Lagranha, C., Levada-Pires, A., Sellitti, D. et al. The effect of glutamine supplementation and physical exercise on neutrophil function. Amino Acids 34, 337–346 (2008). https://doi.org/10.1007/s00726-007-0560-x

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  • DOI: https://doi.org/10.1007/s00726-007-0560-x

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