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Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?

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Summary.

We examined the effects of β-alanine (taurine analogue and taurine transport antagonist), taurine (regarding its role in neutrophil (PMN) immunonutrition) and taurine combined either with L-NAME (inhibitor of •NO-synthase), SNAP (•NO donor), DON (glutamine-analogue and inhibitor of glutamine-requiring enzymes), DFMO (inhibitor of ornithine-decarboxylase) and β-alanine on neutrophil amino- and α-keto acid profiles or important PMN immune functions in order to establish whether taurine transport-, nitric oxide-, glutamine- or ornithine-dependent mechanisms are involved in any of the taurine-induced effects. According to the present findings, the taurine-mediated effect appears to be based primarily on a modulation of important transmembraneous transport mechanisms and only secondarily on directly or indirectly induced modifications in intragranulocytic amino- and α-keto acid homoeostasis or metabolism. Although a direct relation to the parallel observed immunological modifications can only be presumed, these results show very clearly that compositional modifications in the free intragranulocytic amino- and α keto-acid pools coinciding with changes in intragranulocytic taurine levels are relevant metabolic determinants that can significantly influence the magnitude and quality of the granulocytic immune response.

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Authors and Affiliations

  1. Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany

    J. Mühling, K. A. Nickolaus, R. Matejec, T. W. Langefeld, H. Harbach, J. Engel, M. Wolff, K. Weismüller & G. Hempelmann

  2. Dr. Ing. Herbert Knauer GmbH, Berlin, Federal Republic of Germany

    M. Fuchs

  3. University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool, U.K.

    I. D. Welters

  4. Department of Internal Medicine/Infectious Diseases, Charité, Medical School of Humboldt University, Berlin, Federal Republic of Germany

    M. Krüll

  5. Department of Cardiovascular Surgery, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Federal Republic of Germany

    M. C. Heidt

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  1. J. Mühling
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  2. K. A. Nickolaus
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  3. R. Matejec
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  4. T. W. Langefeld
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  5. H. Harbach
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  6. J. Engel
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  7. M. Wolff
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  8. K. Weismüller
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  9. M. Fuchs
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  10. I. D. Welters
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  13. G. Hempelmann
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Authors’ address: Prof. Dr. med. habil. Jörg Mühling, MBA, Clinics of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen and Marburg GmbH, Justus-Liebig-University Giessen, Rudolf-Buchheim-Strasse 7, D-35385 Giessen, Federal Republic of Germany

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Mühling, J., Nickolaus, K., Matejec, R. et al. Which mechanisms are involved in taurine-dependent granulocytic immune response or amino- and α-keto acid homeostasis?. Amino Acids 34, 257–270 (2008). https://doi.org/10.1007/s00726-007-0497-0

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  • DOI: https://doi.org/10.1007/s00726-007-0497-0

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