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Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly)

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Summary.

The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z2)-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.

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Authors and Affiliations

  1. Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, Ancona, Italy

    R. Galeazzi, E. Marcucci, G. Martelli, D. Natali, M. Orena & S. Rinaldi

Authors
  1. R. Galeazzi
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  2. E. Marcucci
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  3. G. Martelli
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  4. D. Natali
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  5. M. Orena
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  6. S. Rinaldi
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Additional information

Authors’ address: Mario Orena, Dipartimento di Scienze e Tecnologie Chimiche, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, Italy

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Galeazzi, R., Marcucci, E., Martelli, G. et al. Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly). Amino Acids 34, 333–336 (2008). https://doi.org/10.1007/s00726-006-0469-9

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  • DOI: https://doi.org/10.1007/s00726-006-0469-9

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