Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer’s disease
The pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease, has been linked to a condition of oxidative and nitrosative stress, arising from the imbalance between increased reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and antioxidant defences or efficiency of repair or removal systems. The effects of free radicals are expressed by the accumulation of oxidative damage to biomolecules: nucleic acids, lipids and proteins. In this review we focused our attention on the large body of evidence of oxidative damage to protein in Alzheimer’s disease brain and peripheral cells as well as in their role in signalling pathways. The progress in the understanding of the molecular alterations underlying Alzheimer’s disease will be useful in developing successful preventive and therapeutic strategies, since available drugs can only temporarily stabilize the disease, but are not able to block the neurodegenerative process.
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- Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nature Rev S18–S25Google Scholar
- Frei, B eds. 1994Natural antioxidants in human health and disease1Academic PressSan DiegoGoogle Scholar
- Gale, CR, Martyn, CN, Cooper, C 1996Cognitive impairment and mortality in a cohort of elderly peopleBr Med312608611Google Scholar
- Jackson, MJ, Papa, S, Bolanos, J, Bruckdorfer, R, Carlsen, H, Elliott, RM, Flier, J, Griffiths, HR, Heales, S, Holst, B, Lorusso, M, Lund, E, Oivind Moskaug, J, Moser, U, Di Paola, M, Polidori, MC, Signorile, A, Stahl, W, Vina-Ribes, J, Astley, SB 2002Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial functionMol Aspects Med23209285PubMedCrossRefGoogle Scholar
- Polidori, MC, Mattioli, P, Aldred, S, Cecchetti, R, Stahl, W, Griffiths, H, Senin, U, Sies, H, Mecocci, P 2004Plasma antioxidant status, immunoglobulin G oxidation and lipid peroxidation in demented patients: relevance to Alzheimer’s disease and vascular dementiaDement Geriatr Cogn Disord18265270PubMedCrossRefGoogle Scholar
- Poon HF, Vaishnav RA, Getchell TV, Getchell ML, Butterfield DA (2005) Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice. Neurobiol Aging (epub ahead of print)Google Scholar
- Ross CA, Poirier MA (2004) Protein aggregation and neurodegenerative disease. Nature Med S10–S17Google Scholar
- Sano, M, Ernesto, C, Thomas, RG, Klauber, MR, Schafer, K, Grundman, M, Woodbury, P, Growdon, J, Cotman, CW, Pfeiffer, E, Schneider, LS, Thal, LJ 1997A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer’s disease. The Alzheimer’s Disease Cooperative StudyN Engl J Med33612161222PubMedCrossRefGoogle Scholar
- Sies, H 1985Oxidative stress: introductory remarksSies, H eds. Oxidative stressAcademic PressOrlando17Google Scholar