Amino Acids

, Volume 32, Issue 4, pp 523–526 | Cite as

Regulation of apoptosis by protein S-nitrosylation

  • J. B. Mannick
Review Article


S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.

Keywords: S-nitrosylation – Apoptosis – Nitric oxide – Caspases – GAPDH – NMDA – Thioredoxin, Ask1, FLIP 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • J. B. Mannick
    • 1
  1. 1.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterU.S.A.

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