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Effect of D-amino acids on some mitochondrial functions in rat liver

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Summary.

 We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

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Authors and Affiliations

  1. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mich. México, , , , , , MX

    J. C. González-Hernández, L. Aguilera-Aguirre, V. Pérez-Vázquez, J. Ramírez, M. Clemente-Guerrero, C. Cortés-Rojo & A. Saavedra-Molina

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  1. J. C. González-Hernández
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  2. L. Aguilera-Aguirre
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  3. V. Pérez-Vázquez
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  4. J. Ramírez
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  5. M. Clemente-Guerrero
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  6. C. Cortés-Rojo
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  7. A. Saavedra-Molina
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Received January 15, 2002 Accepted April 14, 2002 Published online September 4, 2002

Acknowledgements The authors appreciated the partial economical support from Mexican grants of CONACYT (to A.S.-M. during its sabbatical) and CIC-UMSNH (2.5) and critical readings from Rafael Álvarez-González.

Authors' address: Alfredo Saavedra-Molina, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3. C.U., Morelia, Mich. 58030. México, Fax: 52-443-326-5788, E-mail: saavedra@zeus.umich.mx

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González-Hernández, J., Aguilera-Aguirre, L., Pérez-Vázquez, V. et al. Effect of D-amino acids on some mitochondrial functions in rat liver. Amino Acids 24, 163–169 (2003). https://doi.org/10.1007/s00726-002-0317-5

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  • DOI: https://doi.org/10.1007/s00726-002-0317-5

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