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Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy

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Abstract

In this study, spectroscopic, dosimetric and stability characteristics of free radicals formed in acetazolamide (ACE) sample as a result of gamma irradiation in the range of 0–15 kGy were determined using electron paramagnetic resonance (EPR) spectroscopy. For this purpose, by interpreting the spectra of the sample in the 0–100 mW microwave power region, it was determined that two different radicals were formed in the sample. The structures formed after irradiation were attributed to CH3OṄ-(radical I) and -OSOṄH (radical II) radicals. The g-values, hyperfine coupling constants and spectrum contribution ratios of these radicals contributing to the experimental spectrum were also calculated. It has been determined that radical II is quite stable both at high temperature and after a long storage period.

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Data Availability

The authors confirm that the datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Science, Faculty of Education, Dicle University, 21280, Diyarbakır, Turkey

    Kerem Sütçü

  2. Department of Oncology, Faculty of Medicine, Dicle University, 21280, Diyarbakır, Turkey

    Y. Emre Osmanoğlu

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  1. Kerem Sütçü
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  2. Y. Emre Osmanoğlu
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Contributions

KS: conceptualization, methodology, software, validation, formal analysis, investigation, data curation, writing—original draft, writing—review & editing, visualization, supervision. YEO: conceptualization, methodology, resources, data curation, writing—original draft, writing—review & editing, visualization, supervision.

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Correspondence to Kerem Sütçü.

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Sütçü, K., Osmanoğlu, Y.E. Identification of Free Radicals Formed in Gamma-Irradiated Acetazolamide Using Electron Paramagnetic Resonance Spectroscopy. Appl Magn Reson 54, 737–750 (2023). https://doi.org/10.1007/s00723-023-01551-w

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  • DOI: https://doi.org/10.1007/s00723-023-01551-w

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