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Compact NMR Spectroscopy with Shift Reagents

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Abstract

To simplify a nuclear magnetic resonance (NMR) spectra of the targeted molecules, spin–spin decoupling and selective isotope substitution are two distinct approaches. A third one is to increase the applied magnetic field to increase the frequency dispersion of the chemical shift range. While this is a viable option for NMR spectrometers with superconducting magnets, the new generation of compact NMR spectrometers employs permanent magnets with limited variety in field strengths between one and two Tesla. The low-frequency dispersion at these field strengths gives rise to higher order spectra more frequently than at high field. These low-field spectra can be simplified using lanthanide shift reagents, which form complexes with the substrate molecule and increase the frequency dispersion. In this work, the use of lanthanide shift reagents is demonstrated by means of one-dimensional 1H and 19F as well as two-dimensional 19F-19F COSY experiments using a new-generation compact NMR spectrometer.

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Acknowledgments

We gratefully acknowledge Master’s student Anne Nickel for her kind help in performing the experiments and the financial support from Deutsche Forschungsgemeinschaft (DFG Gerätezentrum Pro2NMR), a DFG supported, joint instrumental NMR facility BL 231/46-1 of RWTH Aachen University and KIT Karlsruhe.

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  1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany

    Kawarpal Singh & Bernhard Blümich

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  1. Kawarpal Singh
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  2. Bernhard Blümich
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Correspondence to Kawarpal Singh.

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Singh, K., Blümich, B. Compact NMR Spectroscopy with Shift Reagents. Appl Magn Reson 47, 1135–1146 (2016). https://doi.org/10.1007/s00723-016-0821-5

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  • DOI: https://doi.org/10.1007/s00723-016-0821-5

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