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EPR Detection of Iron Storage in Rat Tissues After Simulated Microgravity Model

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Abstract

By a method of spectroscopy of electron paramagnetic resonance the tissues of rats after exposure of microgravity simulation (model of hindlimb unloading) were investigated. In the tissues of heart, lung, liver and muscles the signals of electron magnetic resonance (EMR) depending on orientation were detected. The temperature and orientation dependences of the signals were studied. Comprehensive analysis of the characteristics of the EMR signals made it possible to identify the source of the signals as a crystalline magnetite. Three types of anisotropic EMR signals corresponding to a variety of spatial forms of accumulation of biogenic magnetite were detected. The appearance of the signals after microgravity simulation indicates an alteration in iron metabolism and an abnormal accumulation of iron in the rat tissues.

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References

  1. M.G. Tairbekov, Gravitational Biology of the Cell (Theory and Experiment) (Moscow Press, Moscow, 1997). (in Russian)

    Google Scholar 

  2. L.I. Kakurin, V.I. Lobachik, V.M. Mikhailov, YuA Senkevich, Aviat. Space Environ. Med. 47(10), 1083–1086 (1976)

    Google Scholar 

  3. E.R. Morey-Holton, R.K. Globu, J. Appl. Physiol. 92, 1367–1377 (2002)

    Article  Google Scholar 

  4. E.A. Kovalenko, Kosmicheskaya Biologiya i Aviakosmicheskaya Meditsina 11(4), 3–9 (1977). (in Russian)

    Google Scholar 

  5. Y. Ohira, T. Wakatsuki, W. Yasui, S. Sugawara, K. Koyanagi, N. Kobayashi, in Proceedings of Third International Symposium on Space Medicine, Nagoya, pp. 299–305 (1992)

  6. F.W. Booth, C.R. Kirby, Am. J. Physiol. 262, R329–R332 (1992)

    Google Scholar 

  7. A.A. Levina, Z.G. Shishkanova, S.M. Ivanova, T.N. Levina, M.M. Tsibulskaya, O.I. Labetskaya, V.V. Karashtin, G.I. Kozinets, Klinicheskaia Laboratornaia Diagnostika 7, 3–5 (1998). (in Russian)

    Google Scholar 

  8. J.L. Kirschvink, D.S. Jones, B.J. MacFadden, Magnetite Biomineralization and Magnetoreception in Organisms (Plenum Press, New York, 1985)

    Book  Google Scholar 

  9. J.L. Kirschvink, Bioelectromagnetics 10, 239–260 (1989)

    Article  Google Scholar 

  10. E. Mosiniewicz-Szablewska, A. Slawska-Waniewska, K. Świątec, N. Nedelko, J. Galazka-Friedman, A. Friedman, Appl. Magn. Reson. 24, 429–435 (2003)

    Article  Google Scholar 

  11. O. Mykhailyk, G. Török, O. Dudchenko, O. Stavinska, N. Dudchenko, F. Steinberg, J. Magn. Magn. Mater. 272–276, 2422–2423 (2004)

    Article  Google Scholar 

  12. J.I. Azhipa, Medical-Biological Aspects of Electron Paramagnetic Resonance Applications (Nauka Press, Moscow, 1983). (in Russian)

    Google Scholar 

  13. A.B. Brik, Miner. J. (Ukraine) 25, 16–26 (2003)

    Google Scholar 

  14. L.G. Abracado, D.M.S. Esquivel, E. Wajnberg, J. Magn. Magn. Mater. 320, e204–e206 (2008)

    Article  ADS  Google Scholar 

  15. H. Li, M.T. Klem, K.B. Sebby, D.J. Singel, M. Young, T. Douglas, Y.U. Idzerda, J. MMM 321, 175–180 (2009)

    ADS  Google Scholar 

  16. M.M. Yulikov, O.N. Martyanov, V.F. Yudanov, Appl. Magn. Res. 23, 105–112 (2002)

    Article  Google Scholar 

  17. O.N. Matryanov, S.N. Trukhan, V.F. Yudanov, Appl. Magn. Res. 33, 57–71 (2008)

    Article  Google Scholar 

  18. V.Yu. Petukhov, N.Yu. Panarina, N.R. Khabibullina, E.P. Zheglov, A.A. Mozhanova, Appl. Magn. Reson. 30, 233–242 (2006)

    Article  Google Scholar 

  19. F. Walz, J. Phys. Condens. Matter 14, R285–R340 (2002)

    Article  ADS  Google Scholar 

  20. S.V. Yurtaeva, V.N. Efimov, N.I. Silkin, A.A. Rodionov, M.V. Burmistrov, A.V. Panov, A.A. Moroshek, Appl. Magn. Reson. 42(3), 299–311 (2012)

    Article  Google Scholar 

  21. A.R. Muxworthy, E. McClelland, Geophys. J. Int. 140, 101–114 (2000)

    Article  ADS  Google Scholar 

  22. R. Řezníček, V. Chlan, H. Štěpánková, P. Novák, M. Maryško, J. Phys. Condens. Matter 24, 055501 (2012)

    Article  Google Scholar 

  23. A.M. Hirt, F. Brem, M. Hanzlik, D. Faivre, J. Geophys. Res. 111(1–10), B12S06 (2006)

    ADS  Google Scholar 

  24. M. Hagiwara, K. Nagata, K. Nagata, J. Phys. Soc. Japan 67(10), 3590–3600 (1998)

    Article  ADS  Google Scholar 

  25. Z.C. Huang, X.F. Hu, Y.X. Xu, Y. Zhai, Y.B. Xu, J. Wu, H.R. Zhai, J. Appl. Phys. 111(1–3), 07C108 (2012)

    Google Scholar 

  26. L. McGuigan, R.C. Barklie, Phys. Rev. B 77(1–9), 174424 (2008)

    Article  ADS  Google Scholar 

  27. L.R. Bickford, Phys. Rev. 78(4), 449–457 (1950)

    Article  ADS  Google Scholar 

  28. A.I. Grigoriev, B.S. Shenkman, Skeletal muscle during unloading. Her. Russian Acad. Sci. 78(4), 337–345 (2008). (in Russian)

    Google Scholar 

  29. M.I. Ibragimova, A.I. Chushnikov, G.V. Cherepnev, V.Yu. Petukhov, E.P. Zheglov, Biophysics 59(3), 425–430 (2014)

    Article  Google Scholar 

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Acknowledgments

The present research by EPR spectroscopy was carried out under the support of Scientific Program of Presidium of RAS 1.26 P during 2015–2016 and rat tissue samples after simulated microgravity model were obtained within the support of Grant RFBR 15-04-05951. V.N. Efimov is also grateful for financial support by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities.

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Authors and Affiliations

  1. E.K.Zavoisky Physical-Technical Institute, The Kazan Scientific Center, The Russian Academy of Sciences, Sibirsky Trakt 10/7, Kazan, 420029, Russia

    S. V. Yurtaeva, G. G. Yafarova, V. S. Iyudin, Kh. L. Gainutdinov & I. V. Yatsyk

  2. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya st. 18, Kazan, 420008, Russia

    V. N. Efimov, G. G. Yafarova, A. A. Eremeev & Kh. L. Gainutdinov

  3. Institute of Physics, Kazan Federal University, Kremlevskayast. 18, Kazan, 420008, Russia

    A. A. Rodionov

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  1. S. V. Yurtaeva
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  2. V. N. Efimov
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  3. G. G. Yafarova
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  4. A. A. Eremeev
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  5. V. S. Iyudin
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  6. A. A. Rodionov
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  7. Kh. L. Gainutdinov
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  8. I. V. Yatsyk
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Correspondence to S. V. Yurtaeva.

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Yurtaeva, S.V., Efimov, V.N., Yafarova, G.G. et al. EPR Detection of Iron Storage in Rat Tissues After Simulated Microgravity Model. Appl Magn Reson 47, 555–565 (2016). https://doi.org/10.1007/s00723-016-0779-3

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  • DOI: https://doi.org/10.1007/s00723-016-0779-3

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