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Self-diffusion of Water and Blood Lipids in Mouse Erythrocytes

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Abstract

The self-diffusion of water and lipids in water—mouse RBCs’ suspension was investigated by pulsed field gradient NMR technique at different diffusion times in temperature range from 5 to 35 °C. For the experimental data interpretation, the phenomenological scaling approach was applied. The intracellular water restriction size (2.1 μm), erythrocyte water permeability (about 10−5 m/s), intracellular residence time (about 20 ms), and water permeability activation energy (24.1 ± 1.9 kJ/mol) were calculated. The lipid self-diffusion coefficients are varied from 3 × 10−12 to 10−11 m2/s depending on temperature and diffusion time. The lipid lateral self-diffusion activation energy is about 25 ± 2.9 kJ/mol.

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Acknowledgments

The authors thank Professor Vladimir Skirda for helpful discussions.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics RAS, Academician Semenov Avenue, 1, Chernogolovka, 142432, Moscow Region, Russia

    Irina A. Avilova, Anastasiya V. Smolina, Alexander I. Kotelnikov, Raisa A. Kotelnikova & Vitaly I. Volkov

  2. Science Center in Chernogolovka RAS, Lesnaya str., 9, Chernogolovka, 142432, Moscow Region, Russia

    Vitaly I. Volkov

  3. Mari State University, Lenin sq., 1, Mari El, 424000, Yoshka-Ola, Russia

    Valentin V. Loskutov

Authors
  1. Irina A. Avilova
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  2. Anastasiya V. Smolina
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  5. Valentin V. Loskutov
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Correspondence to Vitaly I. Volkov.

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Avilova, I.A., Smolina, A.V., Kotelnikov, A.I. et al. Self-diffusion of Water and Blood Lipids in Mouse Erythrocytes. Appl Magn Reson 47, 335–347 (2016). https://doi.org/10.1007/s00723-015-0759-z

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  • DOI: https://doi.org/10.1007/s00723-015-0759-z

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