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Influence of Nature of Functional Groups on Interaction of Tetrasubstituted at Lower Rim p-tert-Butyl Thiacalix[4]arenes in 1,3-Alternate Configuration with Model Lipid Membranes

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Abstract

The influence of p-tert-butyl thiacalix[4]arenes (1,3-alternate) functionalized by N-propyl morpholine, N,N-dipropyliden-amine and aminodiacetate fragments on dynamic structure of liposomal membranes prepared from dipalmitoyl phosphatidylcholine was investigated by means of electron spin resonance spin-probe technique and Fourier transform infrared spectroscopy. Nuclear magnetic resonance and transmission electron microscopy techniques were applied to characterize the interacting systems. The obtained results have shown that all studied calixarenes interact with polar domains of bilayer. Depending on functional groups and hydrophobic/hydrophilic properties of calixarenes they can dip into bilayer, locate close to the surface of bilayer or form bridges between positively charged groups of adjacent lipid molecules, thus assisting to disordering or putting in order the lipid molecules.

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Acknowledgments

The financial support from the Federal Program “Research and Pedagogical Cadre for Innovative Russia” in years 2009–2013 (nr. p1107 on 26 August 2009), program of the Russian Foundation for Basic Research (grant nr. 09-03-00426-a), program of the Russian Federation President grants for the state support of young Russian scientists - doctor of sciences (grant nr. MD-2747.2010.3) is gratefully acknowledged.

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Authors and Affiliations

  1. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russian Federation

    D. A. Fayzullin, N. N. Vylegzhanina, V. V. Salnikov & Yu. F. Zuev

  2. Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russian Federation

    O. I. Gnezdilov

  3. Kazan (Volga Region) Federal University, Kazan, Russian Federation

    A. V. Galukhin, I. I. Stoikov & I. S. Antipin

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  1. D. A. Fayzullin
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  2. N. N. Vylegzhanina
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  3. O. I. Gnezdilov
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  4. V. V. Salnikov
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  5. A. V. Galukhin
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  6. I. I. Stoikov
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  8. Yu. F. Zuev
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Correspondence to Yu. F. Zuev.

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Fayzullin, D.A., Vylegzhanina, N.N., Gnezdilov, O.I. et al. Influence of Nature of Functional Groups on Interaction of Tetrasubstituted at Lower Rim p-tert-Butyl Thiacalix[4]arenes in 1,3-Alternate Configuration with Model Lipid Membranes. Appl Magn Reson 40, 231–243 (2011). https://doi.org/10.1007/s00723-011-0202-z

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  • DOI: https://doi.org/10.1007/s00723-011-0202-z

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