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Uveitis posterior

Posterior Uveitis

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Zusammenfassung

Dieser Artikel bietet einen Überblick über Ursachen und Verläufe von infektöser und nicht-infektöser Uveitis posterior. Er hilft bei der Erstellung von Differenzialdiagnosen und zeigt Therapieoptionen auf.

Summary

This article provides a good overview of the most important causes of infectious and non-infectiousposterior uveitis. It aims at guiding through finding the right diagnosis quickly by approaching the differential diagnoses using the right diagnostic tools. Therapeutic options are being discussed and various possible outcomes are pointed out.

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Literatur

  1. Aaberg TM. Recurrences and bilaterality in the multiple evanescent white-dot syndrome. Am J Ophthalmol. 1985;100(1):29–37.

    Article  CAS  PubMed  Google Scholar 

  2. Abu-Yaghi NE. White dot syndromes: a 20-year study of incidence, clinical features, and outcomes. Ocul Immunol Inflamm. 2011;19(6):426–30.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ahnood D. Punctate inner choroidopathy: a review. Surv Ophthalmol. 2017;62(2):113–26.

    Article  PubMed  Google Scholar 

  4. Akpek EK. Successful treatment of serpiginous choroiditis with alkylating agents. Ophthalmology. 2002;109(8):1506–13.

    Article  PubMed  Google Scholar 

  5. Akpek EK. New treatments for serpiginous choroiditis. Curr Opin Ophthalmol. 2003;14(3):128–31.

    Article  PubMed  Google Scholar 

  6. Algahtani H. Neurological manifestations of acute posterior multifocal placoid pigment epitheliopathy. J Clin Neurol. 2016;12(4):460–7.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Baarsma GS. Serpiginous (geographic) choroiditis. Doc Ophthalmol. 1976;40(2):269–85.

    Article  CAS  PubMed  Google Scholar 

  8. Baglivo E. Multiple evanescent white dot syndrome after hepatitis B vaccine. Am J Ophthalmol. 1996;122(3):431–2.

    Article  CAS  PubMed  Google Scholar 

  9. Bansal R. Tubercular serpiginous choroiditis. J Ophthalmic Inflamm Infect. 2022;12(1):37.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Bousquet E. Birdshot chorioretinopathy: a review. J Clin Med. 2022;11(16):4772.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Brézin AP. HLA-A29 and birdshot chorioretinopathy. Ocul Immunol Inflamm. 2011;19(6):397–400.

    Article  PubMed  Google Scholar 

  12. Brown J. Visual prognosis of multifocal choroiditis, punctate inner choroidopathy, and the diffuse subretinal fibrosis syndrome. Ophthalmology. 1996;103(7):1100–5.

    Article  PubMed  Google Scholar 

  13. Butler NJ. Ocular toxoplasmosis II: clinical features, pathology and management. Clin Exp Ophthalmol. 2013;41(1):95–108.

    Article  PubMed  Google Scholar 

  14. Callanan D. Multifocal choroiditis and choroidal neovascularization associated with the multiple evanescent white dot and acute idiopathic blind spot enlargement syndrome. Ophthalmology. 1992;99(11):1678–85.

    Article  CAS  PubMed  Google Scholar 

  15. Cao JH. Birdshot chorioretinitis lesions on Indocyanine green angiography as an indicator of disease activity. Retina. 2006;36(9):1751–7.

    Article  Google Scholar 

  16. Channa R. Characterization of macular lesions in punctate inner choroidopathy with spectral domain optical coherence tomography. J Ophthalmic Inflamm Infect. 2012;2(3):113–20.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Christmas NJ. Long-term follow-up of patients with serpinginous choroiditis. Retina. 2002;22(5):550–6.

    Article  PubMed  Google Scholar 

  18. Cunningham ET. Uveitis in children. Ocul Immunol Inflamm. 2000;8(4):251–61.

    Article  PubMed  Google Scholar 

  19. dell’Omo R. Multiple evanescent white dot syndrome (MEWDS). Int Ophthalmol Clin. 2012;52(4):221–8.

    Article  PubMed  Google Scholar 

  20. Dick AD. Risk of ocular complications in patients with noninfectious intermediate uveitis, posterior uveitis, or panuveitis. Ophthalmology. 2016; https://doi.org/10.1016/j.ophtha.2015.10.028.

    Article  PubMed  Google Scholar 

  21. Elkins BS. Ocular toxoplasmosis misdiagnosed as cytomegalovirus retinopathy in immunocompromised patients. Ophthalmology. 1994;101(3):499–507.

    Article  CAS  PubMed  Google Scholar 

  22. Essilfie J. Are there two forms of multiple evanescent white dot syndrome? Retina. 2022;42:227–35.

    Article  CAS  PubMed  Google Scholar 

  23. Gass JD. Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol. 1968;80(2):177–85.

    Article  CAS  PubMed  Google Scholar 

  24. Gass JD. Acute zonal occult outer retinopathy: a long-term follow-up study. Am J Ophthalmol. 2002;134(3):329–39.

    Article  PubMed  Google Scholar 

  25. Gelfman S. ERAP1, ERAP2, and two copies of HLA-aw19 alleles increase the risk for birdshot chorioretinopathy in HLA-A29 carriers. Invest Ophthalmol Vis Sci. 2021;62(14):3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Grigg ME. Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J Infect Dis. 2001;184(5):633–9.

    Article  CAS  PubMed  Google Scholar 

  27. Gross NE. Multiple evanescent white dot syndrome. Arch Ophthalmol. 2006;124(4):493–500.

    Article  PubMed  Google Scholar 

  28. Hangai M. Features and function of multiple evanescent white dot syndromw. Arch Ophthalmol. 2009;127(10):1307–13.

    Article  PubMed  Google Scholar 

  29. Holak HM. The pathogenesis of birdshot chorioretinopathy. Surv Ophthalmol. 2006;51(4):446–7.

    Article  PubMed  Google Scholar 

  30. Holland GN. Ocular toxoplasmosis: a global reassessment. Part II: disease manifestations and management. Am J Ophthalmol. 2004;137(1):1–17.

    MathSciNet  PubMed  Google Scholar 

  31. Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc. 1995;93:623–83.

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Jabs DA. Cytomegalovirus retinitis and the acquired immunodeficiency syndrome—bench to bedside: LXVII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011;151(2):198–216.e1.

    Article  PubMed  Google Scholar 

  33. Jampol LM. Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol. 1984;102(5):671–4.

    Article  CAS  PubMed  Google Scholar 

  34. Jampol LM. White spot syndromes of the retina: a hypothesis based on the common genetic hypothesis of autoimmune/inflammatory disease. Am J Ophthalmol. 2003;135(3):376–9.

    Article  PubMed  Google Scholar 

  35. Joye A. Vogt-Koyanagi-Harada disease. Curr Opin Ophthalmol. 2021; https://doi.org/10.1097/icu.0000000000000809.

    Article  PubMed  Google Scholar 

  36. Kuiper JJ. A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy. Hum Mol Genet. 2014;23(22):6081–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Kuo IC. Clinical characteristics and outcomes of cytomegalovirus retinitis in persons without human immunodeficiency virus infection. Am J Ophthalmol. 2004;138(3):338–46.

    Article  PubMed  Google Scholar 

  38. Laatikainen L. Serpiginous choroiditis. Br J Ophthalmol. 1974;58(9):777–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Labalette P. Ocular toxoplasmosis after the fifth decade. Am J Ophthalmol. 2002;133(4):506–15.

    Article  PubMed  Google Scholar 

  40. Langner-Wegscheider BJ. Intravitreal ganciclovir in the management of non-AIDS-related human cytomegalovirus retinitis. Can J Ophthalmol. 2010;45(2):157–60.

    Article  PubMed  Google Scholar 

  41. Li D. Loss of photoreceptor outer segment in acute zonal occult outer retinopathy. Arch Ophthalmol. 2007;125(9):1194–200.

    Article  PubMed  Google Scholar 

  42. Lim W‑K. Serpiginous choroiditis. Surv Ophthalmol. 2005;50(3):231–44.

    Article  PubMed  Google Scholar 

  43. Monnet D. Longitudinal cohort study of patients with birdshot chorioretinopathy. I. Baseline clinical characteristics. Am J Ophthalmol. 2006;141(1):135–42.

    Article  PubMed  Google Scholar 

  44. Monnet D. Longitudinal cohort study of patients with birdshot chorioretinopathy. III. Macular imaging at baseline. Am J Ophthalmol. 2007;144(6):818–28.

    Article  PubMed  Google Scholar 

  45. Monson DM. Acute zonal occult outer retinopathy. Surv Ophthalmol. 2011;56(1):23–35.

    Article  PubMed  Google Scholar 

  46. Mrejen S, et al. Choroidal involvement in acute posterior multifocal placoid pigment epitheliopathy. Ophthalmic Surg Lasers Imaging Retina. 2016;47(1):20–6.

    Article  PubMed  Google Scholar 

  47. Munteanu G. Serpiginous choroiditis—clinical study. Oftalmologia. 2001;52(2):72–80.

    CAS  PubMed  Google Scholar 

  48. Muthiah MN. Acute retinal necrosis: a national population-based study to assess the incidence, methods of diagnosis, treatment strategies and outcomes in the UK. Br J Ophthalmol. 2007;91(11):1452–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Quillen DA. The white dot syndromes. Am J Ophthalmol. 2004;137(3):538–50.

    Article  PubMed  Google Scholar 

  50. Rothova A. Therapy for ocular toxoplasmosis. Am J Ophthalmol. 1993;115(4):517–23.

    Article  CAS  PubMed  Google Scholar 

  51. Ryan SJ. Acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 1972; https://doi.org/10.1007/978-3-540-69000-9_100040.

    Article  PubMed  Google Scholar 

  52. Schoenberger SD. Diagnosis and treatment of acute retinal necrosis: a report by the American academy of ophthalmology. Ophthalmology. 2017;124(3):382–92.

    Article  PubMed  Google Scholar 

  53. Shah KH. Birdshot chorioretinopathy. Surv Ophthalmol. 2005;50(6):519–41.

    Article  PubMed  Google Scholar 

  54. Silveira C. The effect of long-term intermittent trimethoprim/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis. Am J Ophthalmol. 2002;134(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  55. Soheilian M. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. Ophthalmology. 2011;118(1):134–41.

    Article  PubMed  Google Scholar 

  56. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol. 2021;228:174–81.

    Article  Google Scholar 

  57. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for acute retinal necrosis syndrome. Am J Ophthalmol. 2021;228:237–44.

    Article  Google Scholar 

  58. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for Behçet disease uveitis. Am J Ophthalmol. 2021;228:80–8.

    Article  Google Scholar 

  59. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for cytomegalovirus retinitis. Am J Ophthalmol. 2021;228:245–54.

    Article  Google Scholar 

  60. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for multiple evanescent white dot syndrome. Am J Ophthalmol. 2021;228:198–204.

    Article  Google Scholar 

  61. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for punctate inner choroiditis. Am J Ophthalmol. 2021;228:275–80.

    Article  Google Scholar 

  62. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for sarcoidosis-associated uveitis. Am J Ophthalmol. 2021;228:220–30.

    Article  Google Scholar 

  63. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for serpiginous choroiditis. Am J Ophthalmol. 2021;228:126–33.

    Article  Google Scholar 

  64. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for syphilitic uveitis. Am J Ophthalmol. 2021;228:182–91.

    Article  Google Scholar 

  65. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification criteria for toxoplasmic retinitis. Am J Ophthalmol. 2021;228:134–41.

    Article  Google Scholar 

  66. Standardization of Uveitis Nomenclature (SUN) Working Group. Development of classification criteria for the uveitides. Am J Ophthalmol. 2021; https://doi.org/10.1016/j.ajo.2021.03.061.

    Article  PubMed  Google Scholar 

  67. Steiner S, et al. Imaging in the diagnosis and management of APMPPE. Int Ophthalmol Clin. 2012;52(4):211–9.

    Article  PubMed  Google Scholar 

  68. Thomas BC. Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). J Ophthalmic Inflamm Infect. 2012;2(3):125–31.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Thorne JE. Loss of visual field among patients with birdshot chorioretinopathy. Am J Ophthalmol. 2008;145(1):23–8.

    Article  PubMed  Google Scholar 

  70. Urzua CA. Vogt-Koyanagi-Harada disease: the step-by-step approach to a better understanding of clinicopathology, immunopathology, diagnosis, and management: a brief review. J Ophthal Inflamm Infect. 2022;12(1):17.

    Article  CAS  Google Scholar 

  71. Watzke RC. Punctate inner choroidopathy. Am J Ophthalmol. 1984;98(5):572–84.

    Article  CAS  PubMed  Google Scholar 

  72. Weiss H. The clinical course of serpiginous choroidopathy. Am J Ophthalmol. 1979;87(2):133–42.

    Article  CAS  PubMed  Google Scholar 

  73. Workowski KA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137.

    PubMed  Google Scholar 

  74. Xerri O. Untreated acute posterior multifocal placoid pigment epitheliopathy (APMPPE): a case series. BMC Ophthalmol. 2018;18(1):76.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Xu Y. Presumed recurrent MEWDS following Covid-19 vaccination. Ocul Immunol Inflamm. 2021;29(6):1234–7.

    Article  CAS  PubMed  Google Scholar 

  76. Yap SC. Syphilitic uveitis in a Singaporean population. Ocul Immunol Inflamm. 2014;22(1):9–14.

    Article  PubMed  Google Scholar 

  77. Zhang X. Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. Ophthalmology. 2012;120(12):2678–83.

    Article  Google Scholar 

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  1. Augenzentrum Seiersberg, Hagenbuchstrasse 1, 8054, Seiersberg-Pirka, Österreich

    Beate Wegscheider FEBO

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Wegscheider, B. Uveitis posterior. Spektrum Augenheilkd. (2024). https://doi.org/10.1007/s00717-023-00566-9

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