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Verlaufsbeobachtung einer rhinozerebralen Zygomykose bei einem nur teilweise complianten Patienten

Study of rhinocerebral zygomycosis in an only partially compliant patient

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Summary

BACKGROUND: Short description of the pathogenicity of zygomycetes. PATIENT AND METHODS: The patient was observed both clinically and by MRI over a period of two years, starting with the first presentation. RESULTS: Description of the applied and rejected diagnostic and therapeutic options and their results. CONCLUSION: In spite of repeated interruptions of treatment the patient was able to maintain a subjective high quality of life over a period of two years. Visual acuity of the right eye amounts to 1.0 s.c., the left eye became blind one week after the first presentation.

Zusammenfassung

HINTERGRUND: Kurze Darstellung der Pathogenität von Zygomyzeten. PATIENT UND METHODE: Der Patient wurde von der Erstvorstellung über 2 Jahre hinweg klinisch und mittels MRT beobachtet. ERGEBNISSE: Die eingesetzten und abgelehnten Diagnose- und Therapiemöglichkeiten und deren Resultate werden dargestellt. SCHLUSSFOLGERUNG: Trotz mehrmaligem Abbruch der Therapie hat sich der Patient 2 Jahre nach Erkrankungsbeginn eine gute subjektive Lebensqualität erhalten. Der Visus rechts beträgt 1,0 s.c., das linke Auge erblindete 1 Woche nach Erstvorstellung.

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Literatur

  • Roden M M, Zaoutis TE, Buchanan W L, KnudsenTA, Sarkisova T A, Schaufele RL, Sin M, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ (2005) Epidemiology and outcome of Zygomycosis: a review of 929 reported cases. Clin Infect Dis 41: 643–653

    Article  Google Scholar 

  • Rutar T, Cockerham KP (2006) Periorbital zygomycosis (mucormycosis) treated with posaconazol. Am J Ophthalmol 142 (1): 187–188

    Article  PubMed  Google Scholar 

  • Rogers T R (2008) treatment of zygomycosis: current and new options. J Antimicrob Chemother 61 [Suppl 1]: 135–139

    Google Scholar 

  • Thursky KA, Playford EG, Seymour JF, Sorrell TC, Ellis DH, Guy SD, Gilroy N, Chu J, Shaw DR (2008) Recommendations for the treatment of established fungal infections. Int Med J 38: 496–520

    Article  CAS  Google Scholar 

  • Jayalakshmi SS, Reddy RG, Borgohain R, Subramanyam C, Panigrahi M, Sundarm C, Meena AK, Mohandas S (2007) Predictors of mortality in rhinocerebral mycosis. Neurology India 55 (3): 292–297

    Article  PubMed  Google Scholar 

  • Mohr J, Johnson M, Cooper T, Lewis J, Ostrosky-Zeichner L (2008) Current options in antifungal pharmacotherapy. Pharmacotherapy 28 (5): 614–645

    Article  CAS  PubMed  Google Scholar 

  • Lai C-C, Tan C-K, Huang Y-T, Shao P-L, Hsueh P-R (2008) Current challenges in the management of invasive fungal infections. J Infect Chemother 14: 77–85

    Article  CAS  PubMed  Google Scholar 

  • Brown J (2005) Zygomycosis: an emerging fungal infection. Am J Health-System Pharmacy: 12/21/2005

  • Greenberg R N, et al (2006) Posaconazol as salvage therapy for zygomycosis. Antimicrob Agents Chemother 50: 126–133

    Article  CAS  PubMed  Google Scholar 

  • Van Burik J-A H, Hare RS, Solomon HF, Corrado ML, Kontoyannis DP (2006) Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin Infect Dis 42: e61–65

    Article  CAS  PubMed  Google Scholar 

  • Kontoyannis DP, Lewis RE (2006) Invasive zygomycosis: update on pathogenesis, clinical manifestations and management. Infect Dis Clin North Am 20: 581–607

    Article  Google Scholar 

  • Pak J, et al (2008) Mucormycosis in immunochallenged patients. J Emergencies, Trauma and Shock 1 (2): 106–113

    Article  Google Scholar 

  • Ibrahim AS, et al (2007) The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest 117 (9): 2649–2657

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim AS, Spellberg B, Edwards J (2008) Iron aquisitation: a novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis 21: 620–625

    Article  CAS  PubMed  Google Scholar 

  • Kaur IP, Rana C, Singh H (2008) Development of effective ocular preparations of antifungal agents. J Ocul Pharmacol Ther 24 (5): 481–493

    Article  CAS  PubMed  Google Scholar 

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Gruber, I., Lackinger, B. Verlaufsbeobachtung einer rhinozerebralen Zygomykose bei einem nur teilweise complianten Patienten. Spektrum Augenheilkd. 24, 162–165 (2010). https://doi.org/10.1007/s00717-010-0400-3

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  • DOI: https://doi.org/10.1007/s00717-010-0400-3

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