Zusammenfassung
ZIELSETZUNG: Die Bewertung der Korrelation zwischen Wechselstoffkontrolle und Präsenz und Schweregrad der diabetischen Retinopathie (DR) bei Patienten mit Typ-2-Diabetes. METHODEN: Diese Querschnittstudie umfasste 80 Patienten, die in vier Gruppen eingeordnet wurden, nach der Dauer der Krankheit: de novo; bis zu 10 Jahren; 11 bis 20 Jahre; und über 20 Jahre. Um die Stoffwechselkontrolle zu bewerten wurden bei jedem Patient die folgenden Parameter getestet: glycosiliertes Hämoglobin (HbA1c), Gesamtcholesterinspiegel (TC), High-Density Lipoprotein Cholesterin (HDL-C), Low-Density Lipoprotein Cholesterin (LDL-C) und Triglyceride (TG). Abhängig von der Änderung an der Netzhaut wurden die Patienten nach der Klassifizierung der Amerikanischen Akademie für Augenheilkunde eingeordnet. ERGEBNISSE: Patienten mit DR hatten deutlich erhöhte HbA1c-Werte (9,5 ± 1,83%) und verringerte HDL-C-Werte (1,1 ± 0,21 mmol/L) im Vergleich zu Patienten ohne DR (6,9 ± 1,29%, t = 5,088; p < 0,001 und 1,3 ± 0,25 mmol/L, t = 3,022; p < 0,01). Die Präsenz und der Schweregrad der DR standen in positiver Wechselwirkung mit HbA1c-Werten (p < 0,001) und schlechter glykämischer Kontrolle (p < 0,001), während sich HDL-C Werte umgekehrt proportional zur Präsenz (p < 0,01) und zum Schweregrad der DR (p < 0,05) verhielten. SCHLUSSFOLGERUNG: Schlechte Stoffwechselkontrolle, gemessen anhand erhöhter HbA1c-Werte und verringerter HDL-C-Werte, steht in Wechselwirkung mit der Präsenz und dem Schweregrad der DR.
Summary
AIM: To evaluate the correlation between metabolic control and the presence and severity level of diabetic retinopathy (DR) in patients with diabetes type 2. METHODS: This cross-sectional study included 80 patients divided into four groups according to the duration of the disease: de novo; up to 10 years; from 11 to 20 years; and over 20 years. In order to evaluate the metabolic control each patient was tested for: glycosylated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). According to eye fundus changes patients were classified following the American Academy of Ophthalmology classification. RESULTS: The patients with DR had significantly increased values of HbA1c. (9.5 ± 1.83%) and decreased values of HDL-C (1.1 ± 0.21 mmol/L) compared to patients without DR (6.9 ± 1.29%, t = 5.088; p < 0,001) and (1.3 ± 0.25 mmol/L, t = 3.022; p < 0.01) respectively. The presence and severity level of DR correlated positively with HbA1c values (p < 0.001) and poor glycaemic control (p < 0.001) while HDL-C values correlated inversely with the presence (p < 0.01) and severity level of DR (p < 0.05). CONCLUSION: Poor metabolic control determined by the increased values of HbA1c and decreased values of HDL-C correlates with the presence and severity of DR.
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Kosanović-Jaković, N., Resan, M., Dimitrijević-Srećković, V. et al. Metabolic control and diabetic retinopathy in patients with diabetes type 2. Spektrum Augenheilkd. 24, 157–161 (2010). https://doi.org/10.1007/s00717-010-0399-5
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DOI: https://doi.org/10.1007/s00717-010-0399-5
Schlüsselwörter
- Stoffwechselkontrolle
- Diabetische Retinopathie
- Typ-2-Diabetes
- Glykosiliertes Hämoglobin
- High-Density Lipoprotein Cholesterin