Summary
Intravitreal triamcinolone acetonide (IVTA) has been reported successful for macular edema in several pathologies, e. g. diabetic retinopathy, uveitis, and central retinal vein occlusion (CRVO) [1–3]. Recent publications have raised the question of decreased local immunity induced by corticosteroids, and a potentially increased risk for infectious endophthalmitis following IVTA [4]. Cases of retinal necrosis in patients treated with systemic corticosteroids have rarely been reported [5–7]. We report a case of endophthalmitis and necrotizing retinopathy following an intravitreal injection of Triamcinolone acetonide.
Zusammenfassung
Intravitreales Triamcinolon-Acetonide (IVTA) wurde in der Literatur mehrfach in der Behandlung von Makulaödemen unterschiedlicher Genese z. B. bei diabetischer Retinopathie, Uveitis, und bei retinalen Zentralvenenverschlüssen (ZVV) eingesetzt [1–3]. Rezente Publikationen haben das potentielle Risiko einer verminderten lokalen Immunresistenz durch Kortikosteroid-Applikation, sowie die Möglichkeit eines eventuell erhöhten Risikos für infektiöse Endophthalmitis einer IVTA folgend, aufgeworfen [4]. Dokumentierte Fälle von retinalen Nekrosen bei Patienten nach systemischer Kortikosteroid-Behandlung sind selten [5–7]. Wir berichten über einen Fall von Endophthalmitis mit retinaler nekrotisierender Retinopathie nach einer intravitrealen Verabreichung von Triamcinolon Acetonide.
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Aggermann, T., Stolba, U., Brunner, S. et al. Lokale Immunsuppression durch intravitreale Kortikosteroid-Applikation?. Spektrum Augenheilkd. 21, 193–194 (2007). https://doi.org/10.1007/s00717-007-0209-x
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DOI: https://doi.org/10.1007/s00717-007-0209-x