Summary
The human papilloma viruses (HPVs) are known to be causal factors in the development malign tumors. The study investigates a smear test, routinely used in gynecology for HPV-diagnosis in cervical lesions, for oral HPV-detection. The procedure is evaluated and the reliability and potential failures are evaluated. The Digene Cervical Sampler HC2 Hybrid Capture® procedure represents a reliable and low-price method in the diagnosis of high and low risk oral HPV-infection.
Zusammenfassung
Humane Papillomaviren (HPVs) gelten als kausale Ursache bei der Entstehung maligner Tumore. Die vorliegende Untersuchung bewertet die Anwendung der in der Gynäkologie als Routineverfahren verwendeten HPV-Abstrichmethode (Digene Cervical Sampler®) im Rahmen der oralen HPV-Diagnostik. Es wird die Methodik des Verfahrens beschrieben, Reliabilitätsbestimmungen und Fehlermöglichkeiten bewertet und die Studienergebnisse mit Ergebnissen der aktuellen Literatur verglichen. Die Digene Cervical Sampler HC2 Hybrid Capture®-Diagnostik (Digene Cervical Sampler® in Kombination mit Hybrid Capture II® Assay) stellt ein zuverlässiges und kostengünstiges Verfahren in der oralen high-risk- und low-risk-HPV-Diagnostik dar.
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Literatur
Castle PA, Rodriguez AC, Burk RD, Herrero R, Wacholder S, Alfaro M, Morales J, Guillen D, Sherman ME, Solomon D, Schiffman M (2009) Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study. BMJ 339: b2569
D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C,. Koch WM, Westra WH, Gillison ML (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356: 1944–1956
Flores R, Abalos AT, Nielson CM, Abrahamsen M, Harris RB, Giuliano AR (2008) Reliability of sample collection and laboratory testing for HPV detection in men. J Virol Methods 149: 136–143
Gillison M (2010) HPV and Its Effect on Head and Neck Cancer Prognosis. Clin Adv Hematol Oncol 8: 680–682
Gillison ML, Koch WM, Capon RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92: 709–720
Grimm C, Polterauer S (2012) Die Bedeutung der typenspezifischen HPV-Typisierung. Speculum 01/2012: 6–9
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646–674
Hansson BG, Rosenquist K, Antonsson A, Wennerberg J, Schildt EB, Bladstrom A, Andersson G (2005) Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern. Sweden Acta Otolaryngol 125: 1337–1344
Herrero R, Castellsague X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar T, Sridhar H, Rose B, Pintos J, Fernandez L, Idris A, Sanchez MJ, Nieto A, Talamini R, Tavani A, Bosch FX, Reidel U, Snijders PJ, Meijer CJ, Viscidi R, Munoz N, Franceschi S (2003) Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95: 1772–1783
Kreimer AR, Clifford GM, Boyle P, Franceschi S (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 14: 467–475
Lace MJ, Anson JR, Klussmann JP, Wang DH, Smith EM, Haugen TH, Turek LP (2011) Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers. J Virol 85: 1645–1454
Lee JK, Kim MK, Song SH, Hong JH, Min KJ, Kim JH, Song ES, LeeJ , Lee JM, Hur SY (2009) Comparison of human papillomavirus detection and typing by hybrid capture 2, linear array, DNA chip, and cycle sequencing in cervical swab samples. Int J Gynecol Cancer 19: 266–272
Michl P, Pazdera J, Prochazka M, Pink R, Stosova T (2010) Human papillomavirus in the etiology of head and neck carcinomas. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154: 9–12
Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, Moller B, Pukkala E, Schiller JT, Youngman L, Lehtinen M, Dillner J (2001) Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344: 1125–131
Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, Snijders PJ, Meijer CJ (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348: 518–527
Schiffman MH, Schatzkin A (1994) Test reliability is critically important to molecular epidemiology: an example from studies of human papillomavirus infection and cervical neoplasia. Cancer Res 54: 1944s–1947s
Schlecht NF, Burk RD, Adrien L, Dunne A, Kawachi A, Sarta C, Chen Q, Brandwein-Gensler M, Prystowsky MB, Childs G, Smith RV, Belbin TJ (2007) Gene expression profiles in HPV-infected head and neck cancer. J Pathol 213: 283–293
Smith EM, Ritchie JM, Summersgill KF, Klussmann JP, Lee JH, Wang D, Haugen TH, Turek LP (2004) Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 108: 766–772
zur Hausen H (1987) Papillomaviruses in human cancer. Cancer 59: 1692–1696
Zur Hausen H (1988) Papillomaviruses in human cancers. Mol Carcinog 1: 147–150
zur Hausen H (1999) Papillomaviruses in human cancers. Proc Assoc Am Physicians 111: 581–587
zur Hausen H (2009) Papillomaviruses in the causation of human cancers - a brief historical account. Virology 384: 260–265
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Ferderführender Autor: DDr. Daniel Dalla Torre, Klinik für MKG-Chirurgie, Medizinische Universität Innsbruck, Anichstrasse 35, 6020 Innsbruck, Tel.: 0512/504/82509, E-Mail: daniel.dalla-torre@uki.at
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Dalla Torre, D., Sölder, E., Burtscher, D. et al. Die orale Bürstenabstrichmethode zur Bestimmung von humanen Papillomavirus (HPV)-Infektionen. Stomatologie 109, 35–39 (2012). https://doi.org/10.1007/s00715-012-0154-4
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DOI: https://doi.org/10.1007/s00715-012-0154-4