Abstract
High biological activity of natural furocoumarins is often linked to a series of adverse side effects, e.g., genotoxicity. This makes it desirable to develop semi-synthetic derivatives with reduced negative activity while retaining or even enhancing the positive properties. Previously, we have studied the genotoxic activity of a library of twenty-one 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins and identified modifications that minimize the negative properties. In the current article, we report on an investigation into the cytotoxic activity of the same library. We have aimed to rank the substances in order of the severity of their cytotoxicity and therefore to predict, with the use of statistical processing, the most promising substituents for the furocoumarin scaffold.
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Acknowledgements
The investigation of antioxidative activity was supported by Federal program № AAAA-A21-121011490016-8 and by Russian Science Foundation grant № 18-13-00361. Other research was carried out within the state assignment of the Ministry of Science and Higher Education of the Russian Federation FWNR-2022-0017.
The authors thank the Center for Collective Use of Microscopic Analysis of Biological Objects (Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia) for providing the equipment.
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Ivanov, A.A., Ukladov, E.A., Kremis, S.A. et al. Investigation of cytotoxic and antioxidative activity of 1,2,3-triazolyl-modified furocoumarins and 2,3-dihydrofurocoumarins. Protoplasma 259, 1321–1330 (2022). https://doi.org/10.1007/s00709-022-01739-0
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DOI: https://doi.org/10.1007/s00709-022-01739-0