Abstract
Centrioles and centrosomes are found in almost all eukaryotic cells, where they are important for organising the microtubule cytoskeleton in both dividing and non-dividing cells. The spatial location of centrioles and centrosomes is tightly controlled and, in non-dividing cells, plays an important part in cell migration, ciliogenesis and immune cell functions. Here, we examine some of the ways that centrosomes are connected to other organelles and how this impacts on cilium formation, cell migration and immune cell function in metazoan cells.
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Abbreviations
- aPKC:
-
Atypical protein kinase C
- KASH domain:
-
Klarsicht, ANC-1 and Syne/Nesprin homology domain
- IS:
-
Immunological synapse
- LINC complex:
-
Linker of nucleoskeleton and cytoskeleton complex
- MT:
-
Microtubule
- MTOC:
-
mMicrotubule organising centre
- NMII:
-
Non-muscle myosin II
- SUN domain:
-
Sad1 and UNC-84 homology domain
- TCR:
-
T cell receptor
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Acknowledgments
We would like to thank Helen Thompson and Karen Renzaglia for providing some of the TEM images and Jack Chen for assistance with the manuscript.
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The authors declare that they have no competing interests.
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Amy R. Barker and Kate V. McIntosh contributed equally to this work.
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Barker, A.R., McIntosh, K.V. & Dawe, H.R. Centrosome positioning in non-dividing cells. Protoplasma 253, 1007–1021 (2016). https://doi.org/10.1007/s00709-015-0883-5
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DOI: https://doi.org/10.1007/s00709-015-0883-5