Extracellular vesicle-mediated transfer of membranous components from the highly malignant T24 urinary carcinoma cell line to the non-malignant RT4 urinary papilloma cell line

Abstract

This communication reports the first experimental evidence that in the bladder cancer model, membranous components labelled with the DiO dye and the cholera toxin subunit B can be transported from highly malignant (T24) to non-malignant (RT4) cells by extracellular vesicles. Taking into account the presence of stable membranous nanostructures found by scanning electron microscopy, we suggest a possible uptake mechanism in recipient cells through fusion with highly curved membranous regions.

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The authors declare that they have no conflict of interest.

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Correspondence to Veronika Kralj-Iglič.

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Handling Editor: Peter Nick

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Ogorevc, E., Hudoklin, S., Veranič, P. et al. Extracellular vesicle-mediated transfer of membranous components from the highly malignant T24 urinary carcinoma cell line to the non-malignant RT4 urinary papilloma cell line. Protoplasma 251, 699–702 (2014). https://doi.org/10.1007/s00709-013-0544-5

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Keywords

  • Intercellular transfer
  • Extracellular vesicles
  • Exosomes
  • Microvesicles
  • DiO
  • Cholera toxin