Summary.
The reactions of 1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid and its ethyl ester with alkyl and aryl isothiocyanates under mild conditions resulted in the corresponding thiohydantoin-fused tetrahydro-β-carbolines. Treatment of the ethyl ester with isocyanates furnished ethyl 2-alkyl- or arylcarbamoyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylates which were transformed to hydantoin-fused tetrahydro-β-carbolines. The structures of the thiohydantoin compounds, involving two conformers and the presence of keto-enol tautomerism, were determined by NMR spectroscopy.
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Received February 2, 2002. Accepted (revised) March 4, 2002
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Solymár, M., Palkó, M., Martinek, T. et al. Synthesis of Imidazo[1′,5′:1,2]pyrido[3,4-b]indole Derivatives. Monatshefte für Chemie 133, 1423–1430 (2002). https://doi.org/10.1007/s007060200114
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DOI: https://doi.org/10.1007/s007060200114