Summary.
ω-Chloroalkyl biliverdins, prepared in three steps from 8-unsubstituted dipyrrinones in 70–80% overall yields, were reduced by sodium borohydride to provide the corresponding ω-chloroalkyl bilirubins in high yields. Upon treatment of the ω-chloroalkyl biliverdins with sodium hydroxide in ethanol, C12-N22 bridged biliverdins were obtained in high yields.
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Received December 13, 2000. Accepted January 15, 2001
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Tu, B., Chen, Q., Yan, F. et al. Efficient Routes to ω-Chloroalkyl Bilirubins and C12-N22 Bridged Biliverdins. Monatshefte fuer Chemie 132, 693–705 (2001). https://doi.org/10.1007/s007060170084
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DOI: https://doi.org/10.1007/s007060170084