Summary.
A hypericin derivative containing ω,ω ′-4-dimethylaminobenzal residues was shown to undergo an intramolecular [2 + 2] cycloaddition upon irradiation leading to a cyclobutane derivative whose main absorption band is hardly shifted as compared to hypericin. The corresponding ω-substituted derivative displayed a 34 nm bathochromic shift and a strongly reduced fluorescence quantum yield rendering it a nice candidate for a photodynamic therapy agent. Unfortunately, however, it produced virtually no photosensitized active oxygen species, making it thus unsuited for this purpose.
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Received July 11, 2001. Accepted July 18, 2001
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Obermüller, R., Falk, H. Concerning the Absorption and Photochemical Properties of an ω-4-Dimethylaminobenzal Hypericin Derivative. Monatshefte für Chemie 132, 1519–1526 (2001). https://doi.org/10.1007/s007060170009
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DOI: https://doi.org/10.1007/s007060170009