Summary.
The synthesis of a new chiral boroxazolidine was achieved which was used to control the stereochemistry of the borane reduction of the 20-keto group of steroids. The otherwise hardly accessible 20α-(20S)-alcohol can thus be prepared in a yield of 91%.
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Received April 10, 2000. Accepted (revised) May 2, 2000
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Göndös, G., Dombi, G. & Orr, J. A New Chiral Director for the Highly Diastereoselective Borane Reductionof Steroid-20-ones. Monatshefte für Chemie 131, 1055–1059 (2000). https://doi.org/10.1007/s007060070037
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DOI: https://doi.org/10.1007/s007060070037