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Microwave Activated Solid Support Synthesis of New Antibacterial Quinolones

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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary.

 A novel synthesis of 6-fluoro-7-(5-aryl-1,3,4-thiadiazol/oxadiazol-2-yl-sulfanyl)-4-quinolone-3-carboxylic acids from 7-chloro-6-fluoro-4-quinolone-3-carboxylic acid and 5-substituted 1,3,4-thiadiazoles/oxadiazoles on basic alumina under microwave activation is described. All compounds were screened for their in vitro antibacterial activity against B. lichenformis, 2689, K. aerogens 2281, S. typhimurium 2501, E. herbicola 2491, and P. vulgaris 2027 and found to possess activities comparable to that of the standard drug norfloxacin.

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Authors and Affiliations

  1.  Department of Chemistry, University of Delhi, Delhi-110007, India, , , , , , IN

    Mazaahir Kidwai, Preeti Misra, Bhavesh Dave & Kumar R. Bhushan

  2.  Deparment of Microbiology, University of Delhi, South Campus, New Delhi-110021, India, , , , , , IN

    Rajendra K. Saxena & Meena Singh

Authors
  1. Mazaahir Kidwai
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  2. Preeti Misra
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  3. Bhavesh Dave
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  4. Kumar R. Bhushan
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  5. Rajendra K. Saxena
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  6. Meena Singh
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Additional information

Received May 2, 2000. Accepted (revised) June 13, 2000

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Kidwai, M., Misra, P., Dave, B. et al. Microwave Activated Solid Support Synthesis of New Antibacterial Quinolones. Monatshefte fuer Chemie 131, 1207–1212 (2000). https://doi.org/10.1007/s007060070029

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  • DOI: https://doi.org/10.1007/s007060070029

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