Summary.
Upon condensation with 4-isothiocyanato-4-methyl-2-pentanone, 2,3-diaminonaphthalene and N-aminoethyladenosine gave in good yields substituted pyrimidonaphthoimidazole and imidazopyrimidine thione. Refluxing pyrimidobenzthiazole with methanol H2SO4 at pH∼1 resulted in S-methyl pyrimidobenzthiazole in moderate yield. Pyrimidobenzimidazole derivatives could be reacted to S-alkylated and N-acylated derivatives by refluxing with ethyl bromoacetate in the presence of anhydrous potassium carbonate in THF and by heating in an acetic acid/acetic anhydride mixture. Heating of pyrimidobenzimidazole with 75% aqueous H2SO4 on a water bath ended up in a rearranged product. All compounds gave correct 1H NMR, IR, and HR mass spectra. Results of antiinflammatory, analgesic, and anticancer activity screening of the new compounds are described.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received October 29, 1999. Accepted (revised) January 13, 2000
Rights and permissions
About this article
Cite this article
Sondhi, S., Singhal, N., Verma, R. et al. Synthesis and Antiinflammatoryand Anticancer Activity Evaluation of Some Condensed Pyrimidines. Monatshefte für Chemie 131, 501–509 (2000). https://doi.org/10.1007/s007060050331
Issue Date:
DOI: https://doi.org/10.1007/s007060050331