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Ferric oxide nanocatalyst: synthesis, characterization, and application in the one-pot three-component synthesis of 3,4,5-trisubstituted isoxazole derivatives

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Abstract

In this study, we have focused on the preparation and application of a nano-ferric oxide catalyst as a heterogeneous catalyst in the one-pot, three-component synthesis of isoxazole derivatives. The ferric oxide catalyst was synthesized using a simple precipitation method and thoroughly characterized using techniques such as FT-IR, XRD, SEM, EDX, and BET. The effectiveness of the ferric oxide catalyst as a heterogeneous catalyst was investigated in the synthesis of 3,4,5-trisubstituted isoxazole. The results of the synthesis demonstrated that the catalyst exhibited high efficiency in facilitating the three-component, one-pot synthesis of 3,4,5-trisubstituted isoxazole derivatives. The synthesis route employed in this study offers several advantages, including its simplicity, ease of workup, and environmental friendliness. Furthermore, the catalyst was successfully recovered and reused for five cycles without experiencing a significant loss in catalytic activity. This finding highlights the excellent stability and promising potential of the catalyst for organic transformations. Overall, our study showcases the successful preparation and application of the nano-ferric oxide catalyst in the synthesis of isoxazole derivatives, providing valuable insights into its catalytic performance and potential for future applications in organic chemistry.

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The spectroscopic data of the products are available in the supplementary information.

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Acknowledgements

The authors are thankful to the management and principal of PDEA's Ramkrishna More College Akurdi (Pune) for their encouragement, as well as the Central Instrumentation Facility (CIF) of Savitribai Phule Pune University and the SAIF CDRIL Lucknow for providing spectral data.

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Authors and Affiliations

  1. Department of Chemistry, Prof. Ramkrishna More College, Akurdi, Pune, 411044, India

    Ganesh Totre & Dnyaneshwar Shinde

  2. Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, 411008, India

    Sachin Shirsath

  3. Department of Chemistry, Dr Arvind Telang Senior College of Arts, Science and Commerce, Nigdi, Pune, 411044, India

    Prakash Patil

  4. Department of Chemistry and Post Graduate Research Center in Organic Chemistry, Hutatma Rajguru Mahavidyalaya (Affiliated to Savitribai Phule Pune University, Pune), Rajgurunagar, Pune, 410505, India

    Pramod Kulkarni

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  1. Ganesh Totre
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  2. Dnyaneshwar Shinde
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  4. Prakash Patil
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Correspondence to Pramod Kulkarni.

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Totre, G., Shinde, D., Shirsath, S. et al. Ferric oxide nanocatalyst: synthesis, characterization, and application in the one-pot three-component synthesis of 3,4,5-trisubstituted isoxazole derivatives. Monatsh Chem (2024). https://doi.org/10.1007/s00706-024-03194-4

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  • DOI: https://doi.org/10.1007/s00706-024-03194-4

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