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A highly sensitive chloramphenicol detection sensor based on a carbon-graphite nanocomposite modified with silver nanoparticles application: human serum and urine

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Abstract

A highly sensitive Ag NPs@CPE sensor based on a carbon–graphite nanocomposite modified with silver nanoparticles was developed for the electrochemical determination of a drug, the antibiotic chloramphenicol. Electrochemical tests showed that the Ag NPs@CPE electrode had a higher electrochemical activity and a larger effective surface area than the bare electrode. X-ray diffraction and scanning electron microscopy demonstrated the presence of carbon-supported silver particles with a narrow size distribution, providing evidence for the effect of particle size on the electrocatalytic detection efficiency of chloramphenicol. Under optimal conditions, the modified Ag NPs@CPE electrode exhibited an excellent response at the linear detection range was 1.0 × 10–3–1.0 × 10–7 mol/dm3 and a detection limit of 6.19 × 10–8 mol/dm3. The RSD values are 2.66% for repeatability and 3.02% for reproducibility. The proposed sensor provides remarkable selectivity and satisfactory recovery for real chloramphenicol-contaminated human urine and serum samples.

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Authors and Affiliations

  1. Team of Catalysis and Environment, Faculty of Sciences, Ibn Zohr University, BP 8106, Agadir, Morocco

    Jallal Zoubir, Ali Assabbane & Idriss Bakas

  2. Environmental, Ecological and Agroindustrial Energineering Laboratory, University Moulay Slimane, 23000, Beni-Mellal, Morocco

    Abdessamad Tounsi

  3. Organic and Analytical Chemistry Laboratory, Faculty of Science and Technology, Univ. Sultan Moulayslimane, 23000, Beni-Mellal, Morocco

    Yassine Elkhotfi

Authors
  1. Jallal Zoubir
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  2. Yassine Elkhotfi
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  3. Abdessamad Tounsi
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  4. Ali Assabbane
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  5. Idriss Bakas
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Correspondence to Jallal Zoubir.

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Zoubir, J., Elkhotfi, Y., Tounsi, A. et al. A highly sensitive chloramphenicol detection sensor based on a carbon-graphite nanocomposite modified with silver nanoparticles application: human serum and urine. Monatsh Chem 154, 837–848 (2023). https://doi.org/10.1007/s00706-023-03090-3

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  • DOI: https://doi.org/10.1007/s00706-023-03090-3

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