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An efficient multicomponent synthesis of fused pyrido-dipyrimidines containing tranexamic acid under green conditions

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Abstract

An efficient protocol was exploited to synthesize pyrido-dipyrimidines containing tranexamic acid moiety as a pharmaceutically interesting core via facile, highly efficient one-pot multicomponent reactions. The products were formed within a short time from the reaction of barbituric acid, tranexamic acid, and a variety of aryl aldehydes in water at room temperature under air conditions.

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Acknowledgements

We are grateful to Dr. Hooman Kaghazian (Director of Celltech Accelerator) for helping us with financial support.

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Authors and Affiliations

  1. Department of Chemistry, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran

    Faezeh Yazdian, Sorour Ramezanpour & Kazem Mahmoudzadeh

  2. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1434875451, Iran

    Seyed Abdulmajid Ayatollahi

  3. Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada

    Atefe Ghodrati

Authors
  1. Faezeh Yazdian
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  2. Sorour Ramezanpour
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  3. Seyed Abdulmajid Ayatollahi
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  4. Atefe Ghodrati
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  5. Kazem Mahmoudzadeh
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Correspondence to Sorour Ramezanpour or Seyed Abdulmajid Ayatollahi.

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Yazdian, F., Ramezanpour, S., Ayatollahi, S.A. et al. An efficient multicomponent synthesis of fused pyrido-dipyrimidines containing tranexamic acid under green conditions. Monatsh Chem 154, 223–229 (2023). https://doi.org/10.1007/s00706-022-03027-2

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  • DOI: https://doi.org/10.1007/s00706-022-03027-2

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