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One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst

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Abstract

The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag3PO4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines.

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Data availability

Data analyzed in this work were a re-analysis of existing data, which are openly available at locations cited in the reference section. Further documentation about data processing and analysis are available as supplementary data.

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Authors and Affiliations

  1. Organic, Inorganic Chemistry, Electrochemistry, and Environment Laboratory, University of Ibn Tofail, Faculty of Sciences, Po Box 133, 14000, Kenitra, Morocco

    Achraf El Hallaoui, Youssef Merroun, Soukaina Chehab, Rachida Ghailane & Abdelaziz Souizi

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  1. Achraf El Hallaoui
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  2. Youssef Merroun
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  3. Soukaina Chehab
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  4. Rachida Ghailane
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  5. Abdelaziz Souizi
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Correspondence to Achraf El Hallaoui or Abdelaziz Souizi.

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El Hallaoui, A., Merroun, Y., Chehab, S. et al. One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst. Monatsh Chem 154, 231–237 (2023). https://doi.org/10.1007/s00706-022-03023-6

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  • DOI: https://doi.org/10.1007/s00706-022-03023-6

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