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Nanographene laser-pyrolyzed paper electrodes for the impedimetric detection of d-glucose via a molecularly imprinted polymer

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Abstract

In this proof-of-concept study, we used laser-pyrolyzed paper as the supporting electrodes for the swift, impedimetric, and enzymeless detection of d-glucose by the means of molecularly imprinted polymer. Molecular imprinting of monomer 3-amino-4-hydroxybenzoic acid was performed by electrochemical polymerization in the presence of d-glucose as a template molecule, followed by the template removal process via cyclic voltammetry in PBS (pH = 7.4). The analytical capacitance signal was extracted from the raw electrochemical impedance spectra recorded after only 60 s of incubation with the analyte. The electrodes were characterized by Raman spectroscopy and scanning electron microscopy to disclose their structural and morphological properties, revealing the presence of nanographene of high porosity. The analytical performance was investigated in the clinically relevant range of 0–30 mmol dm−3, which demonstrated good linearity (r2 = 0.97), decent limit of detection (1.77 mmol dm−3), an excellent selectivity (ɑ = 1.38–3.73), and good reproducibility (5.0%).

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Acknowledgements

This research was supported by São Paulo Research Foundation (FAPESP) [Grant numbers: 2017/10522-5, 2018/14425-7, 2018/08782-1, 2018/13922-7, 2019/11214-8], Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES: 001) [Pró-Forenses Edital 25/2014] and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [Grant Number: 305605/2017-8, and 302839/2020-8, 145833/2020-8].

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Authors and Affiliations

  1. Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo (USP), São Paulo, SP, Brazil

    Bruna Bossard, Renata Antunes Grothe, Alisson Bezerra Martins, Alnilan Lobato, Nikola Tasić, Thiago R. L. C. Paixão & Luís Moreira Gonçalves

  2. Department of Analytical Chemistry, National Institute of Chemistry, Ljubljana, Slovenia

    Alnilan Lobato & Nikola Tasić

  3. International Postgraduate School Jožef Štefan, Ljubljana, Slovenia

    Alnilan Lobato

  4. Instituto Nacional de Ciência e Tecnologia de Bioanalítica, Campinas, SP, 13084-971, Brazil

    Thiago R. L. C. Paixão

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  1. Bruna Bossard
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  2. Renata Antunes Grothe
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Correspondence to Nikola Tasić.

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Bossard, B., Grothe, R.A., Martins, A.B. et al. Nanographene laser-pyrolyzed paper electrodes for the impedimetric detection of d-glucose via a molecularly imprinted polymer. Monatsh Chem 153, 1129–1135 (2022). https://doi.org/10.1007/s00706-022-02997-7

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