Ferulic acid (FA) is one of the cinnamic acid derivatives and abundantly available in most cereals, fruits (orange), and vegetables (tomato, carrot). It has been characterized for its therapeutic potential against several diseases and disorders such as diabetes and Alzheimer’s. It exhibits promising antioxidant, anti-inflammatory, anticancer, and antiallergic, and many more properties. In the present study, the FA has been investigated for therapeutic insights through interaction behavior with protein and calculating binding and thermodynamic parameters at marked temperatures. Circular dichroism was employed for analyzing the secondary structure of the protein. The non-enzymatic glycation process was checked with parameters such as fructosamine and carbonyl content, total advanced glycated end products (AGEs), and individual AGE content spectroscopically. The glycation-induced aggregates of amyloid β-structure were measured with thioflavin-T and visualized using SDS-PAGE. The results indicate that the FA-provided physiological binding constant, Kb equals 1.364 × 104 M−1 at 25 ° C with bovine serum albumin (BSA). The dynamic interaction was observed to be spontaneous with negative Gibb’s energy. The FA potentially suppressed the glycated product formation and protein aggregation. Therefore, these findings suggest that FA may be a useful therapeutic drug candidate for the antiglycation and antiaggregation processes.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Kumar D, Desa A, Chougle S, Bhatkalkar SG, Sachar S, Selvaa KC, Ali A (2021). J Biomol Struct Dyn. https://doi.org/10.1080/07391102.2021.1912642
Jiao Q, Wang R, Jiang Y, Liu B (2018) Chem Cent J 12:1
Yasseen ZJ, Hammad JH, ALTalla HA (2014) Spectrochim Acta A. Mol Biomol Spectrosc 124:677
Liu J, He Y, Liu D, He Y, Tang Z, Lou H, Hou Y, Cou X (2018) RSC Adv 8:7280
Jahanban-Esfahlan A, Panahi-Azar V, Sajedi S (2015) Biopolymers 103:638
Nusrat S, Siddiqi MK, Zaman M, Zaidi N, Ajmal MR, Alam P, Qadeer A, Abdelhameed AS, Khan RH (2016) PLoS ONE 11:e0158833
Sułkowska A (2002) J Mol Str 614:227
Joshi R, Jadhao M, Kumar H, Ghosh SK (2017) Bioorg Chem 75:332
Ojha H, Mishra K, Hassan MI, Chaudhury NK (2012) Thermochim Acta 548:56
Kumar N, Pruthi V (2014) Biotechnol Rep 4:86
Cota-Arriola O, Plascencia-Jatomea M, Lizardi-Mendoza J, Robles-Sánchez R, Ezquerra-Brauer J, Ruíz-García J, Vega-Acosta JR, Cortez-Rocha MO (2017) CyTA - J Food 15:65
Moldovan M, Lahmar A, Bogdan C, Părăuan S, Tomuţă I, Crişan M (2017) Clujul Med 90:212
Tee-Ngam P, Nunant N, Rattanarat P, Siangproh W, Chailapakul O (2013) Sensors 13:13039
Ou S, Kwok KC (2004) J Sci Food Agric 84:1261
Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H (2018) Skin Pharmacol Physiol 31:332
Miranda HV, El-Agnaf OM, Outeiro TF (2016) Mov Disord 31:782
Hao C, Xu G, Wang T, Lv Z, Zhu K, Li B (2017) Russ J Phys Chem B 11:140
Kou SB, Lin ZY, Wang BL, Shi JH, Liu YX (2021) J Mol Struct 1224:129024
Jalali F, Dorraji PS, Mahdiuni H (2014) J Lumin 148:347
Li S, Huang K, Zhong M, Guo J, Wang W-Z, Zhu R (2010) Spectrochim Acta A: Mol Biomol Spectrosc 77:680
Ghazanfari-Sarabi S, Habibi-Rezaei M, Eshraghi-Naeeni R, Moosavi-Movahedi AA (2019) PLoS ONE 14:e0214725
Alam MF, Varshney S, Khan MA, Laskar AA, Younus H (2018) Int J Biol Macromol 113:300
Satish L, Millan S, Das S, Jena S, Sahoo H (2017) J Solution Chem 46:831
Awasthi S, Saraswathi N (2015) RSC Adv 5:87660
Sompong W, Cheng H, Adisakwattana S (2015) PLoS ONE 10:e0129495
Chang HK, Hsu FL, Liu IM, Cheng JT (2003) J Pharm Pharmacol 55:833
Silván JM, Assar SH, Srey C, Del Castillo MD, Ames JM (2011) Food Chem 128:208
Sompong W, Meeprom A, Cheng H, Adisakwattana S (2013) Molecules 18:13886
Adisakwattana S (2017) Nutrients 9:163
Meng G, Meng X, Ma X, Zhang G, Hu X, Jin A, Zhao Y, Liu X (2018) Front Neuroinform 12:31
Kumar D, Bhatkalkar SG, Sachar S, Ali A (2020) J Biomol Struct Dyn 39:6918
Gutierrez RMP (2012) Evid Based Complement Alternat Med 2012:598638
Kelly SM, Price NC (2000) Curr Protein Pept Sci 1:349
Shamsi A, Ahmed A, Khan MS, Husain FM, Bano B (2020) Int J Biol Macromol 161:187
Rondeau P, Armenta S, Caillens H, Chesne S, Bourdon E (2007) Arch Biochem Biophys 460:141
The study was funded by the Research Society for the Study of Diabetes in India (RSSDI/HQ/Grants/2017/342).
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Khan, J., Kumar, D. & Ali, A. Molecular insight into the antiglycating and antiaggregating potential of ferulic acid with BSA. Monatsh Chem 153, 1277–1285 (2022). https://doi.org/10.1007/s00706-022-02983-z