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Fluctuation of internal standard method calibration factors based on a Taguchi designed experiment while alcoholic products analysis with GC–MS

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Abstract

This paper assesses the fluctuation of relative response factors (RRFs) for the quality control of alcoholic products by GC–MS, using two internal standard (IS) methods, namely, a commonly used IS method using 1-pentanol, and “Ethanol as IS” method. To evaluate the variation of calibration factors values the Taguchi designed experiment was used. Matrix composition, volatile compounds concentrations, injected volume of the sample, GC injector temperature and split ratio were the five selected control factors. Within the experiment each of these control factors took one from three possible values to create 27 various measuring conditions. The results of the experiment revealed, that relative standard deviations of RRFs within all 27 measuring conditions were 7.3 ± 4.1% for the 1-pentanol method and 36.3 ± 3.5% for the ethanol method. The possible reasons of calibration factors variation were also discussed.

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Acknowledgements

This work was financially supported by the Visegrad Fund and by the Grant Agency of Charles University SVV 260560.

Funding

This research was supported by International Visegrad Fund (Grant 52110042).

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Authors and Affiliations

  1. Faculty of Science, Department of Analytical Chemistry, Charles University, Prague, Czech Republic

    Anton Korban, Radomír Čabala & Zuzana Bosáková

  2. Chemistry Faculty, Department of Analytical Chemistry, Belarusian State University, Minsk, Belarus

    Anton Korban & Vladimir Egorov

  3. Institute for Nuclear Problems, Belarusian State University, Minsk, Belarus

    Siarhei Charapitsa & Svetlana Sytova

Authors
  1. Anton Korban
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  2. Radomír Čabala
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  3. Vladimir Egorov
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  4. Siarhei Charapitsa
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  5. Zuzana Bosáková
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  6. Svetlana Sytova
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Correspondence to Radomír Čabala.

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Korban, A., Čabala, R., Egorov, V. et al. Fluctuation of internal standard method calibration factors based on a Taguchi designed experiment while alcoholic products analysis with GC–MS. Monatsh Chem 153, 745–751 (2022). https://doi.org/10.1007/s00706-022-02942-8

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  • DOI: https://doi.org/10.1007/s00706-022-02942-8

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