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Synthesis and bioactivity evaluation of 5,6-epoxynorcantharidin mono-amide and imide derivatives

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Abstract

A series of 5,6-epoxynorcantharidin mono-amide and imide derivatives were designed and synthesized. MTT cell inhibition experiment shows that 5,6-epoxy compounds have good biological activity compared with the corresponding 5,6-olefin compounds and their hydrogenated products.

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Acknowledgements

We thank the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University for HRMS determination and tumor cell inhibition test. We also thank Engineering Teaching Experiment Center, School of Chemical Engineering for 1H NMR, 13C NMR, and melting points determination.

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Authors and Affiliations

  1. School of Chemical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China

    Guangliang Chen, Jiyu Gao, Wencai Huang & Zicheng Li

  2. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    Yinglan Zhao

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  1. Guangliang Chen
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  2. Jiyu Gao
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  3. Wencai Huang
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  4. Zicheng Li
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  5. Yinglan Zhao
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Correspondence to Zicheng Li.

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Chen, G., Gao, J., Huang, W. et al. Synthesis and bioactivity evaluation of 5,6-epoxynorcantharidin mono-amide and imide derivatives. Monatsh Chem 153, 359–367 (2022). https://doi.org/10.1007/s00706-022-02905-z

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  • DOI: https://doi.org/10.1007/s00706-022-02905-z

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