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Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides

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Abstract

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2(dppf)2 associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug molecules.

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Acknowledgements

The author gratefully acknowledges financial support from the Hebei Social Science Foundation (HB19YJ062) and Hebei Chemical & Pharmaceutical College. The author is thankful to Hebei University of Science & Technology for 13C-NMR, 1H-NMR, HRMS(ESI) measurement.

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  1. Department of Chemistry and Environmental Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang, People’s Republic of China

    Yan Li

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  1. Yan Li
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Correspondence to Yan Li.

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Li, Y. Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides. Monatsh Chem 153, 193–199 (2022). https://doi.org/10.1007/s00706-021-02881-w

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  • DOI: https://doi.org/10.1007/s00706-021-02881-w

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