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Fabrication of PAMP/Au and GO/PAMP/Au nanosensors for electrochemical detection of paracetamol in pharmaceutical preparations

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Abstract

This paper reports on the modification of Pencil Graphite Electrode (PGE) surface with the poly(2-amino-4-methylphenol)/gold (PAMP/Au) and graphene oxide/poly(2-amino-4-methylphenol)/gold (GO/PAMP/Au) nanocomposites, in two steps. The first step is based on the one-pot preparation of composites by template-free chemical oxidation process. In the second step, composites are deposited at PGE surface by electro-oxidation process. Both nanocomposites and modified PGE surfaces are characterized by X-Ray Diffraction method (XRD), Scanning Electron Microscopy (SEM), EDAX, and CV analyses. The electrochemical performances of modified electrodes (abbreviated as PAMP/Au-PGE and GO/PAMP/Au-PGE) were investigated. The limit of detection values for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE were found to be 2.74 × 10–6, 5.29 × 10–7, and 2.91 × 10–8 mol/dm3, respectively. The limit of quantification values were determined as 9.14 × 10–6, 1.76 × 10–6, and 9.69 × 10–8 mol/dm3 for PGE, PAMP/Au-PGE, and GO/PAMP/Au-PGE, respectively.

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References

  1. Jóźwiak-Bebenista M, Nowak JZ (2014) Acta Pol Pharm 71:11

    PubMed  Google Scholar 

  2. Goyal RN, Gupta VK, Oyama M, Bachheti N (2005) Electrochem Commun 7:803

    Article  CAS  Google Scholar 

  3. Kachoosangi RT, Wildgoose GG, Compton RG (2008) Anal Chim Acta 618:54

    Article  CAS  PubMed  Google Scholar 

  4. El-Said WA, Nasr O, Soliman AIA, Elshehy EA, Khan ZA, Abdel-Wadood FK (2021) Appl Surf Sci Adv 4:100065

    Article  Google Scholar 

  5. Calinescu O, Badea IA, Vladescu L, Meltzer V, Pincu E (2012) J Chromatogr Sci 50:335

    Article  CAS  PubMed  Google Scholar 

  6. Moreira AB, Oliveira HPM, Atvars TDZ, Dias ILT, Neto GO, Zagatto EAG, Kubota LT (2005) Anal Chim Acta 539:257

    Article  CAS  Google Scholar 

  7. Knochen M, Giglio J, Reis BF (2003) J Pharm Biomed Anal 33:191

    Article  CAS  PubMed  Google Scholar 

  8. Sekar R, Kailasa SK, Li W-S, Wu HC, Wu HF (2013) Chin Chem Lett 24:833

    Article  CAS  Google Scholar 

  9. Srivastava MK, Ahmad S, Singh D, Shukla IC (1985) Analyst 110:735

    Article  CAS  PubMed  Google Scholar 

  10. Pourkarim F, Rahimpour E, Khoubnasabjafari M, Jouyban-Gharamaleki V, Gharakhani A, Jouyban A (2021) Chem Pap 75:2901

    Article  CAS  Google Scholar 

  11. Power AC, Gorey B, Chandra S, Chapman J (2018) Nanotechnol Rev 7:19

    Article  CAS  Google Scholar 

  12. Mehretie S, Admassie S, Tessema M, Solomon T (2011) Anal Bioanal Electrochem 3:38

    Google Scholar 

  13. Yin H, Shang K, Meng X, Ai S (2011) Microchim Acta 175:39

    Article  CAS  Google Scholar 

  14. Su WY, Cheng SH (2010) Electroanalysis 22:707

    Article  CAS  Google Scholar 

  15. Pinyou P, Blay V, Chansaenpak K, Lisnund S (2020) Chemosensors 8:133

    Article  CAS  Google Scholar 

  16. Gan T, Hu S (2011) Microchim Acta 175:1

    Article  CAS  Google Scholar 

  17. Yin PT, Kim T-H, Choi J-W, Lee K-B (2013) Phys Chem Chem Phys 15(31):12785

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Parnianchi F, Nazari M, Maleki J, Mohebi M (2018) Int Nano Lett 8:229

    Article  CAS  Google Scholar 

  19. Weaver CL, Li H, Luo X, Cui XT (2014) J Mater Chem B 2:5209

    Article  CAS  PubMed  Google Scholar 

  20. Ebrahim S, Shokry A, Khalil MMA, Ibrahim H, Soliman M (2020) Sci Rep 10:13617

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Kong Y, Li J, Wu S, Cheng W, Rana RK, Zhu J-J (2013) Sens Actuators B 183:187

    Article  CAS  Google Scholar 

  22. Soni A, Pandey CM, Solanki S, Sumana G (2015) RSC Adv 5:45767

    Article  CAS  Google Scholar 

  23. Choudhary M, Siwal SS, Taher A, Mallick K (2015) J Mater Sci 50:6087

    Article  CAS  Google Scholar 

  24. Showkat AM, Cao XT, Kim DW, Islam MR, Lim KT (2015) IOP Conf Ser Mater Sci Eng 77:012007

    Article  Google Scholar 

  25. Link S, El-Sayed MA (1999) J Phys Chem B 103:8410

    Article  CAS  Google Scholar 

  26. Mallick K, Witcomb MJ, Erasmus R, Scurrell MS (2007) Mater Sci Eng B 140:166

    Article  CAS  Google Scholar 

  27. Yu H, Zhang B, Bulin C, Li R, Xing R (2016) Sci Rep 6:36143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Johra FT, Lee JW, Jung WG (2014) J Ind Eng Chem 20:2883

    Article  CAS  Google Scholar 

  29. Mondal S, Rana U, Bhattacharjee RR, Malik S (2014) RSC Adv 4:57282

    Article  CAS  Google Scholar 

  30. Kumar A, Joshi L, Prakash R (2013) Ind Eng Chem Res 52:9374

    Article  CAS  Google Scholar 

  31. Ozcan L (2019) AKU J Sci Eng 19:291

    Google Scholar 

  32. Li W, Li D, Xiao H, He B (2015) High Perform Polym 28:993

    Article  Google Scholar 

  33. Zidan M, Tee TW, Abdullah AH, Zainal Z, Kheng GJ (2011) Int J Electrochem Sci 6:279

    CAS  Google Scholar 

  34. Keskin E, Erturk AS (2018) Ionics 24:4043

    Article  CAS  Google Scholar 

  35. Patil SM, Sataraddi SR, Bagoji AM, Pathan RM, Nandibewoor ST (2014) Electroanalysis 26:831

    Article  CAS  Google Scholar 

  36. Zidan M, Tee TW, Abdullah AH, Zainal Z, Kheng GJ (2011) E-J Chem 8:553

    Article  CAS  Google Scholar 

  37. Can S, Yilmaz S, Saglikoglu G, Sadikoglu M, Menek N (2015) Electroanalysis 27:2431

    Article  CAS  Google Scholar 

  38. Engin C, Yilmaz S, Saglikoglu G, Yagmur S, Sadikoglu M (2015) Int J Electrochem Sci 10:1916

    Google Scholar 

  39. Mocak J, Bond AM, Mitchell S, Scollar G (1997) Pure Appl Chem 69:297

    Article  CAS  Google Scholar 

  40. Miller JN, Miller JC (2005) Statistics and Chemometrics for Analytical Chemistry, 5th edn. Pearson Education Limited, England

    Google Scholar 

  41. European Medicines Agency ICH Topic Q2 (R1) (1995) Validation of Analytical Procedures: Text and Methodology, London https://www.ema.europa.eu/documents/scientific-guideline/ich-q-2-r1-validation-analytical-procedures-text-methodology-step-5_en.pdf. Accessed 19 Oct 2021

  42. Felix FS, Brett CMA, Angnes L (2007) J Pharm Biomed Anal 43:1622

    Article  CAS  PubMed  Google Scholar 

  43. Gowda JI, Nandibewoor ST (2014) Electrochim Acta 116:326

    Article  CAS  Google Scholar 

  44. Tasic ZZ, Mihajlovic MBP, Simonovic AT, Radovanovic MB, Antonijevic MM (2021) Results Phys 22:103911

    Article  Google Scholar 

  45. Fan Y, Liu JH, Lu H-T, Zhang Q (2011) Colloids Surf B 85:289

    Article  CAS  Google Scholar 

  46. Chitravathi S, Munichandraiah N (2016) J Electroanal Chem 764:93

    Article  CAS  Google Scholar 

  47. Koyun O, Gorduk S, Arvas MB, Sahin Y (2018) Russ J Electrochem 54:796

    Article  CAS  Google Scholar 

  48. Yilmaz S, Baş Z, Sadikoglu M, Sultan Y, Gulsen S (2016) Int J Electrochem Sci 11:6244

    Article  CAS  Google Scholar 

  49. Kushwaha CS, Shukla SK (2020) ACS Appl Polym Mater 2:2252

    Article  CAS  Google Scholar 

  50. Atta NF, Galal A, Azab SM (2011) Int J Electrochem Sci 6:5082

    CAS  Google Scholar 

  51. Zidan M, Zawawi RM, Erhayem M, Salhin A (2014) Int J Electrochem Sci 9:7605

    Google Scholar 

  52. Kang X, Wang J, Wu H, Liu J, Aksay IA, Lin Y (2010) Talanta 81:754

    Article  CAS  PubMed  Google Scholar 

  53. European Pharmacopoeia 5.0 Suppl 4.1.3. Buffer solutions (2005) Strasbourg, Cedex, Council of Europe

  54. Chen J, Yao B, Li C, Shi G (2013) Carbon 64:225

    Article  CAS  Google Scholar 

  55. Basavaraja C, Kim WJ, Kim YD, Huh DS (2011) Mater Lett 65:3120

    Article  CAS  Google Scholar 

  56. Bard AJ, Faulkner LR (2006) Electrochemical Methods: Fundamentals and Applications. Wiley, New York

    Google Scholar 

  57. Laviron E (1979) J Electroanal Chem Interfacial Electrochem 100:263

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank Çanakkale Onsekiz Mart University Scientific Research Commission (FBA-2021-3426) for the financial support. They thank Atabay İlaç ve İnce Kimya A.Ş. (İstanbul-Turkey) for supplying pure PCT and its Parol® tablets.

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Authors and Affiliations

  1. Faculty of Sciences and Arts, Department of Chemistry, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Ali Bilici, Nuray Denizhan & Selehattin Yilmaz

  2. Vocational School of Health Services, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Deniz Emre

  3. Department of Biotechnology and ASUBTAM M. Bilmez BioNanoTech Lab., Aksaray University, Aksaray, Turkey

    Caner Soylukan & Fatih Algi

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  1. Ali Bilici
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  2. Nuray Denizhan
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  6. Selehattin Yilmaz
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Correspondence to Ali Bilici or Selehattin Yilmaz.

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Bilici, A., Denizhan, N., Emre, D. et al. Fabrication of PAMP/Au and GO/PAMP/Au nanosensors for electrochemical detection of paracetamol in pharmaceutical preparations. Monatsh Chem 152, 1539–1552 (2021). https://doi.org/10.1007/s00706-021-02866-9

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  • DOI: https://doi.org/10.1007/s00706-021-02866-9

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