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Green route for the synthesis of 3-substituted indoles using [bmim]HSO4 as non-halogenated ionic liquid

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Abstract

In this paper, an effective procedure is reported for the synthesis of 3-substituted indoles via the one-pot three-component reaction of an aldehyde, malononitrile or ethyl cyanoacetate and indole in the presence of [bmim]HSO4 in ethanol under reflux condition. The advantages of this protocol are the synthesis of some novel 3-substituted indoles containing furyl, 4-hydroxyphenyl, and styryl nuclei that are very important in pharmaceutical and drug discovery research in comparison to previously reported results, and the use of non-halogenated ionic liquid.

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Authors and Affiliations

  1. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    Maral Shekarchi & Farahnaz K. Behbahani

  2. Food and Drug Laboratory Research Center, Food and Drug Organization, MOH & ME, Tehran, Iran

    Maryam Shekarchi

Authors
  1. Maral Shekarchi
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  2. Farahnaz K. Behbahani
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  3. Maryam Shekarchi
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Correspondence to Farahnaz K. Behbahani.

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Shekarchi, M., Behbahani, F.K. & Shekarchi, M. Green route for the synthesis of 3-substituted indoles using [bmim]HSO4 as non-halogenated ionic liquid. Monatsh Chem 152, 659–664 (2021). https://doi.org/10.1007/s00706-021-02782-y

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  • DOI: https://doi.org/10.1007/s00706-021-02782-y

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