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Application of new aptasensor modified with nanocomposite for selective estradiol valerate determination in pharmaceutical and real biological samples

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Abstract

In this study, we developed a highly sensitive aptasensor based on polyaniline electro-polymerization, new nanomembrane composite, and aptamer (PANI-MWCNT@Chs-APT) for the electrochemical detection of estradiol valerate in real samples. The high sensitivity and selectivity of the aptasensor were demonstrated by evaluating its response to some potential interference having structural similarities. The selectivity of this aptasensor showed high selectivity for estradiol valerate among other interfering hormones. Electrochemical impedance spectroscopy combined with the standard added method used to characterize the modified gold electrodes as well as for the detection of estradiol valerate both in pharmaceutical and in women’s blood. It showed that the response of the aptasensor rose with increasing estradiol valerate concentration, which highlighted the good sensitivity of the aptasensor to estradiol valerate with a very low limit of detection of 0.56 fM. This was very promising for rapid analysis of estradiol valerate detection in pharmaceutical and biological samples.

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Authors and Affiliations

  1. Laboratory of Sensors, Instrumentations and Process (LCIP), Institute of Science and Technology, Abbes Laghrour University, 40000, Khenchela, Algeria

    Amina Touati & Messaoud Benounis

  2. Laboratory of Analytical Sciences, University Claude Bernard, Lyon 143, Boulevard of 11 November 1918, 69622, Villeurbanne Cedex, France

    Mohamed Braiek & Nicole Jaffrezic-Renault

Authors
  1. Amina Touati
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  2. Mohamed Braiek
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  3. Messaoud Benounis
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  4. Nicole Jaffrezic-Renault
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Correspondence to Amina Touati.

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Touati, A., Braiek, M., Benounis, M. et al. Application of new aptasensor modified with nanocomposite for selective estradiol valerate determination in pharmaceutical and real biological samples. Monatsh Chem 152, 577–585 (2021). https://doi.org/10.1007/s00706-021-02773-z

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  • DOI: https://doi.org/10.1007/s00706-021-02773-z

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