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Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

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Abstract

The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1–0.5 µM with a limit of detection (LOD) of 2.0 × 10–8 M and a limit of quantification (LOQ) of 6.7 × 10–8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1–0.9 µM was obtained with a LOD of 2.6 × 10–8 M and a LOQ of 8.8 × 10–8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10–8 and 8.6 × 10–8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.

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Acknowledgements

We are grateful to the Ministry of Education, Science and Technological Development of the Republic of Serbia for the financial support (Contract Nos. 451-03-68/2020-14/200135, 451-03-68/2020-14/200026, and 451-03-68/2020-14/200168).

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Authors and Affiliations

  1. Department of Electrochemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Belgrade, Serbia

    Jelena Lović & Milka Avramov Ivić

  2. Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia

    Jelena Lađarević, Nemanja Trišović, Dušan Mijin & Slobodan Petrović

  3. Faculty of Chemistry, University of Belgrade, Belgrade, Serbia

    Filip Andrić

  4. Hemofarm Stada A.D, Vršac, Serbia

    Aleksandar Mladenović

  5. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

    Dragan Vuković

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  1. Jelena Lović
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  2. Jelena Lađarević
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  9. Milka Avramov Ivić
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Correspondence to Jelena Lović.

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Lović, J., Lađarević, J., Trišović, N. et al. Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution. Monatsh Chem 152, 185–192 (2021). https://doi.org/10.1007/s00706-021-02745-3

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  • DOI: https://doi.org/10.1007/s00706-021-02745-3

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